Zininga Groep
??GROEPLEIER: Dr Tawanda Zininga??
Posisie: Lektor
Kantoor: A101 JC Smuts Building
Foon: +27-(0)21-808-5870
Faks: +27-(0)21-808-5863
Epos: tzininga@sun.ac.za
Opvoedkundige en Professionele agtergrond
Lektor, Departement Biochemie, Stellenbosch Universiteit SA (2020-)
Nadoktorale genoot, Departement Biochemie, Universiteit van Venda SA (2016-2019)
PhD Biochemie (Universiteit van Venda, SA, 2016)
MSc Molekulere Biologie (Staffordshire 中国体育彩票, UK, 2012)
Honneurs in Baccalaureus van Mediese Laboratorium Wetenskappe (Universiteit van Zimbabwe, ZW, 2005)
Navorsingsfokus
Sel-stresbiologie, proteienvouding, biomerkers, anti-malaria middel ontwerp en ontdekking.
Navorsingsopsomming
Die Zininga Groep fokus op die ondersoek van die rol van molekulere begeleiders in proteienvouding in selle onder stres. Ons hooffokus is op die malaria agente Plasmodium spp. Die parasiete is afhanklik van robuuste proteienvoudingsmasjinerie vir hulle oorlewing in stresvolle omgewings. Ons hoop om die parasiet se proteienvoudingsisteem beter te verstaan en ons beoog om hierdie kennis toe te pas op ander siektes.
Geselekteerde publikasies
Volle lys op ResearchGate: https://www.researchgate.net/profile/Tawanda_Zininga
Zininga, T. and Shonhai A. (2014) Are heat shock proteins druggable candidates? American Journal of Biochemistry and Biotechnology, 10: 211-213.
Zininga, T., Achilonu, I., Hoppe, H., Prinsloo, E. Dirr, HW. Shonhai A (2016). Plasmodium falciparum Hsp70-z (Hsp110c) exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide dependent fashion. Cell Stress and Chaperones, 21(3): 499–513.
Makhoba, XH, Burger, A. Coertzen, D., Zininga, T., Birkholtz, L-M., Shonhai, A. (2016). Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase protein produced in Escherichia coli. PLOS One 11(3): e0152626.
Zininga T. Pooe, OJ, Makhado, PB, Ramatsui, L, Prinsloo, E, Achilonu, I, Dirr, H, Shonhai, A. (2017). Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70. Cell Stress and Chaperones, 22(5): 707-715
Zininga, T., Ramatsui, L., Shonhai, A. (2018) Heat shock proteins as Immunomodulants. Molecules, 23 (11), 2846.
Chakafana, G, Zininga, T, Shonhai, A. (2019) Comparative structure-function features of Hsp70s of Plasmodium falciparum and human origins. Biophysical Reviews, 11, 591–602.
Zininga T, Shonhai A. (2019) Small molecule inhibitors targeting the heat shock protein system of human obligate protozoan parasites. International Journal of Molecular Sciences. 20(23): e5930. ?
