中国体育彩票

图片

Afdeling Geneeskundige Fisiologie

?Publikasies

?

2020

1. Adams KT, Donald PR, Abulfathi AA, Diacon AH, Stander MA, Reuter H. Pharmacokinetics of Para‐Aminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance. J Clin Pharmacol 2020; 60: 489–494.

2. Alabi TD, de Villiers C, du Plessis SS, Monsees TK, Brooks NL, Oguntibeju OO. The beneficial role of anchomanes difformis in stz-induced reproductive dysfunction in male wistar rats. Diabetes, Metab Syndr Obes Targets Ther 2020; 13: 4553–4560.

3. Barrera N, Ordoqui R, Montes JM, Canepa M, Bonelli C, Surka C et al. The Uruguayan semen donor population: A twenty‐eight‐year retrospective study. Andrologia 2020; 52: e13502.

4. Bisimwa BC, Nachega JB, Warren RM, Theron G, Metcalfe JZ, Shah M et al. Xpert Mycobacterium tuberculosis/Rifampicin–Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications. Clin Infect Dis 2020. doi:10.1093/cid/ciaa873.

5. Braissant O, Theron G, Friedrich SO, Diacon AH, Bonkat G. Comparison of isothermal microcalorimetry and BACTEC MGIT960 for the detection of the metabolic activity of Mycobacterium tuberculosis in sputum samples. J Appl Microbiol 2020; 128: 1497–1502.

6. Cerf ME. Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes. Metabolites 2020; 10: 452.

7. Cerf ME. Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes. Metabolites 2020; 10: 444.

8. Cilliers K, Muller CJF. Effect of human immunodeficiency virus on the brain: A review. Anat Rec 2020; : ar.24573.

9. Cilliers K, Muller CJF, Page BJ. Trace Element Concentration Changes in Brain Tumors: A Review. Anat Rec 2020; 303: 1293–1299.

10. Dludla P V., Johnson R, Mazibuko-Mbeje SE, Muller CJF, Louw J, Joubert E et al. Fermented rooibos extract attenuates hyperglycemia-induced myocardial oxidative damage by improving mitochondrial energetics and intracellular antioxidant capacity. South African J Bot 2020; 131: 143–150.

11. Dludla P V, Nyambuya TM, Johnson R, Silvestri S, Orlando P, Mazibuko-Mbeje SE et al. Metformin and heart failure-related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials. Heart Fail Rev 2020; : 1–9.

12. Dludla P V., Muller CJF, Louw J, Mazibuko-Mbeje SE, Tiano L, Silvestri S et al. The Combination Effect of Aspalathin and Phenylpyruvic Acid-2-O-β-d-glucoside from Rooibos against Hyperglycemia-Induced Cardiac Damage: An In Vitro Study. Nutrients 2020; 12: 1151.

13. Dludla P V., Nkambule BB, Mazibuko-Mbeje SE, Nyambuya TM, Marcheggiani F, Cirilli I et al. N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature. Antioxidants 2020; 9: 1283.

14. Dludla P V., Orlando P, Silvestri S, Marcheggiani F, Cirilli I, Nyambuya TM et al. Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. Int J Mol Sci 2020; 21: 3247.

15. Dludla P V., Silvestri S, Orlando P, Gabuza KB, Mazibuko-Mbeje SE, Nyambuya TM et al. Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies. Nutrients 2020; 12: 739.

16. Dludla P V., Silvestri S, Orlando P, Mazibuko-Mbeje SE, Johnson R, Marcheggiani F et al. Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: The critical role of coenzyme Q9/10. Toxicol Vitr 2020; 68: 104948.

17. Erasmus M, Samodien E, Lecour S, Cour M, Lorenzo O, Dludla P et al. Linking LOXL2 to Cardiac Interstitial Fibrosis. Int J Mol Sci 2020; 21: 5913.

18. Eshleman SH, Piwowar‐Manning E, Wilson EA, Lennon D, Fogel JM, Agyei Y et al. Determination of HIV status and identification of incident HIV infections in a large, community‐randomized trial: HPTN 071 (PopART). J Int AIDS Soc 2020; 23: e25452.

19. Everson F, Martens DS, Nawrot TS, Goswami N, Mthethwa M, Webster I et al. Personal exposure to NO2 and benzene in the Cape Town region of South Africa is associated with shorter leukocyte telomere length in women. Environ Res 2020; 182: 108993.

20. Faraj A, Svensson RJ, Diacon AH, Simonsson USH. Drug effect of clofazimine on persisters explains an unexpected increase in bacterial load in patients. Antimicrob Agents Chemother 2020; 64. doi:10.1128/AAC.01905-19.

21. Fourie CMT, Botha-Le Roux S, Smith W, Schutte AE, Breet Y, Mels CMC et al. Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry: Baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study. BMC Infect Dis 2020; 20: 473.

22. Willmer T, Goedecke JH, Dias S, Louw J, Pheiffer C. DNA methylation of FKBP5 in South African women: Associations with obesity and insulin resistance. Clin Epigenetics 2020; 12: 141.

23. Hlengwa N, Muller CJF, Basson AK, Bowles S, Louw J, Awortwe C. Herbal supplements interactions with oral oestrogen‐based contraceptive metabolism and transport. Phyther Res 2020; 34: 1519–1529.

24. Huang SH, Kao YH, Muller CJF, Joubert E, Chuu CP. Aspalathin-rich green Aspalathus linearis extract suppresses migration and invasion of human castration-resistant prostate cancer cells via inhibition of YAP signaling. Phytomedicine 2020; 69: 153210.

25. Hudson P, Woudberg NJ, Kamau F, Strijdom H, Frias MA, Lecour S. HIV-related cardiovascular disease: Any role for high-density lipoproteins? Am. J. Physiol. - Hear. Circ. Physiol. 2020; 319: H1221–H1226.

26. Johnson R, Nxele X, Cour M, Sangweni N, Jooste T, Hadebe N et al. Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model. Sci Rep 2020; 10: 12352.

27. Dhanabalan K, Huisamen B, Lochner A. Mitochondrial oxidative phosphorylation and mitophagy in myocardial ischaemia/reperfusion: Effects of chloroquine. Cardiovasc J Afr 2020; 31: 169–179.

28. Dhanabalan K, Mzezewa S, Huisamen B, Lochner A. Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment. Cardiovasc Drugs Ther 2020; 34: 799–811.

29. Kotzé-H?rstmann LM, Sadie-Van Gijsen H. Modulation of Glucose Metabolism by Leaf Tea Constituents: A Systematic Review of Recent Clinical and Pre-clinical Findings. J. Agric. Food Chem. 2020; 68: 2973–3005.

30. Lochner A. In memoriam: Lionel Opie. J Mol Cell Cardiol 2020; 142: 135–136.

31. Lochner A, Genade S, Genis A, Marais E, Salie R. Long-chain free fatty acids inhibit ischaemic preconditioning of the isolated rat heart. Mol Cell Biochem 2020; 473: 111–132.

32. Maarman GJ. A philosophical perspective on pulmonary hypertension: What is 'rare'? S. Afr. J. Sci. 2020; 116: 1–1.

33. Maarman GJ. Making a case for metallothioneins conferring cardioprotection in pulmonary hypertension. Med Hypotheses 2020; 137: 109572.

34. Maarman GJ, Chakafana G, Sliwa K. World Heart Day: a World Heart Federation communiqué on the future of basic sciences and translational medicine in global cardiovascular research. 2020. doi:10.1152/ajplung.00339.2020.

35. Maarman GJ, Shaw J, Allwood B. Pulmonary hypertension in majority countries: opportunities amidst challenges. Curr Opin Pulm Med 2020; 26: 373–383.

36. Marincowitz C, Webster I, Westcott C, Goswami N, De Boever P, Seidel G et al. Cardiovascular Topics Vascular health assessment with flow-mediated dilatation and retinal image analysis: a pilot study in an adult population from Cape Town. CVJ Africa 2020; 31: 1–8.

37. Cardona Maya WD, Du Plessis SS, Velilla PA. SARS-CoV-2 and the testis: similarity with other viruses and routes of infection. Reprod. Biomed. Online. 2020; 40: 763–764.

38. Mentoor I, Nell T, Emjedi Z, van Jaarsveld PJ, de Jager L, Engelbrecht AM. Decreased Efficacy of Doxorubicin Corresponds With Modifications in Lipid Metabolism Markers and Fatty Acid Profiles in Breast Tumors From Obese vs. Lean Mice. Front Oncol 2020; 10: 306.

39. Millar DA, Bowles S, Windvogel SL, Louw J, Muller CJF. Effect of Rooibos ( Aspalathus linearis ) extract on atorvastatin‐induced toxicity in C3A liver cells. J Cell Physiol 2020; 235: 9487–9496.

40. Mishra H, Reeve BWP, Palmer Z, Caldwell J, Dolby T, Naidoo CC et al. Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study. Lancet Respir Med 2020; 8: 368–382.

41. Nono Nankam PA, Mendham AE, Jaarsveld PJ, Adams K, Fortuin‐de Smidt MC, Clamp L et al. Exercise Training Alters Red Blood Cell Fatty Acid Desaturase Indices and Adipose Tissue Fatty Acid Profile in African Women with Obesity. Obesity 2020; 28: 1456–1466.

42. Nono Nankam PA, van Jaarsveld PJ, Chorell E, Fortuin-de Smidt MC, Adams K, Blüher M et al. Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study. Nutrients 2020; 12: 1619.

43. Ntamo Y, Samodien E, Muller CJF, Louw J, Chellan N. Popular three-dimensional models: Advantages for cancer, Alzheimer's and cardiovascular diseases. Tissue Cell. 2020; 65: 101367.

44. Omolaoye TS, Adeniji AA, Cardona Maya WD, du Plessis SS. SARS-COV-2 (中国体育彩票) and male fertility: Where are we? Reprod Toxicol 2021; 99: 65–70.

45. Omolaoye TS, du Plessis SS. Male infertility: A proximate look at the advanced glycation end products. Reprod. Toxicol. 2020; 93: 169–177.

46. Omolaoye TS, Du Plessis SS. The effect of streptozotocin induced diabetes on sperm function: a closer look at AGEs, RAGEs, MAPKs and activation of the apoptotic pathway. Toxicol Res 2021; 37: 35–46.

47. Pheiffer C, Dias S, Adam S. Intimate Partner Violence: A Risk Factor for Gestational Diabetes. Int J Environ Res Public Health 2020; 17: 7843.

48. Pheiffer C, Willmer T, Dias S, Abrahams Y, Louw J, Goedecke JH. Ethnic and Adipose Depot Specific Associations Between DNA Methylation and Metabolic Risk. Front Genet 2020; 11. doi:10.3389/fgene.2020.00967.

49. Sadie-Van Gijsen H, Kotzé-H?rstmann L, Huisamen B. An In Vivo/Ex Vivo Study Design to Investigate Effects of Chronic Conditions and Therapeutic Compounds on Adipose Stem Cells in Animal Models. In: Methods in Molecular Biology. Humana Press Inc., 2020, pp 101–118.

50. Sangweni NF, Moremane M, Riedel S, van Vuuren D, Huisamen B, Mabasa L et al. The Prophylactic Effect of Pinocembrin Against Doxorubicin-Induced Cardiotoxicity in an In Vitro H9c2 Cell Model. Front Pharmacol 2020; 11: 1172.

51. Shabalala SC, Dludla P V., Mabasa L, Kappo AP, Basson AK, Pheiffer C et al. The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling. Biomed. Pharmacother. 2020; 131: 110785.

52. Smit M, Coetzee AR, Lochner A. The Pathophysiology of Myocardial Ischemia and Perioperative Myocardial Infarction. J. Cardiothorac. Vasc. Anesth. 2020; 34: 2501–2512.

53. Smit SE, Manirafasha C, Marais E, Johnson R, Huisamen B. Cardioprotective Function of Green Rooibos (Aspalathus linearis) Extract Supplementation in Ex Vivo Ischemic Prediabetic Rat Hearts. Planta Med 2020. doi:10.1055/a-1239-9236.

54. Schalkwyk MS Van, Windvogel S, Strijdom H. Rooibos (Aspalathus linearis) protects against nicotine-induced vascular injury and oxidative stress in Wistar rats. Cardiovasc J Afr 2020; 31: 81–90.

55. Viraragavan A, Hlengwa N, De Beer D, Riedel S, Miller N, Bowles S et al. Model development for predicting: In vitro bio-capacity of green rooibos extract based on composition for application as screening tool in quality control. Food Funct 2020; 11: 3084–3094.

56. Xhakaza L, Abrahams-October Z, Mohammednur MM, Pearce B, Adeniyi OV, Johnson R et al. Socio-demographic and modifiable risk factors of diabetes and hypertension among resource constrained patients from rural areas in mdantsane township in South Africa. Afr Health Sci 2020; 20: 1344–1354.

57. Xhakaza L, Abrahams-October Z, Pearce B, Masilela CM, Adeniyi OV, Johnson R et al. Evaluation of the suitability of 19 pharmacogenomics biomarkers for individualized metformin therapy for type 2 diabetes patients. Drug Metab Pers Ther 2020. doi:10.1515/dmdi-2020-0111.

58. Yoshida T, Malherbe CJ, Okon K, Miura Y, Hattori M, Matsuda H et al. Enhanced production of Th1- and Th2-type antibodies and induction of regulatory T cells in mice by oral administration of Cyclopia extracts with similar phenolic composition to honeybush herbal tea. J Funct Foods 2020; 64: 103704.

59. Ziqubu K, Dludla P V., Joubert E, Muller CJF, Louw J, Tiano L et al. Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications. Pharmacol. Res. 2020; 158: 104867.

60. Windvogel S.  Rooibos ( Aspalathus linearis ) and Honeybush ( Cyclopia spp.): From Bush Teas to Potential Therapy for Cardiovascular Disease. In: Nutraceuticals - Past, Present and Future. IntechOpen, 2020 doi:10.5772/intechopen.86410.


2019

1. ABULFATHI AA, DECLOEDT EH, SVENSSON EM, DIACON AH, DONALD PR, REUTER H. Clinical Pharmacokinetics and Pharmacodynamics of Rifampicin in Human Tuberculosis. CLINICAL PHARMACOKINETICS 2019; 58:1103-1129.

2. ADAMS KT, DONALD PR, ABULFATHI AA, DIACON AH, STANDER MA, REUTER H. Pharmacokinetics of Para‐Aminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance. JOURNAL OF CLINICAL PHARMACOLOGY 2019; 0(0):doi.org/10.1002/jcph.1542 (1-6).

3. AGGERBECK H, RUHWALD M, HOFF ST, TINGSKOV PN, HELLSTROM E, MALAHLEHA M, SIEBERT M, GANI M, DIACON AH, ET AL (ENIGMA CONSORTIUM) C. Interaction between C-Tb and PPD given concomitantly in a split-body randomised controlled trial. International Journal of Tuberculosis and Lung Disease 2019; 23(1):38-44.

4. BERNER K, STRIJDOM JG, ESSOP MF, WEBSTER I, MORRIS LD, LOUW QA. Fall history and associated factors among adults living with HIV-1 in the Cape Winelands, South Africa: An exploratory investigation. Open Forum Infectious Diseases 2019; 6(10):ofz401, 7 pages.

5. BLIGNAUT M, ESPACH Y, VAN VUUREN MA, KARTHIK D, HUISAMEN B. Revisiting the Cardiotoxic Effect of Chloroquine. Cardiovascular Drugs and Therapy 2019; 33:s10557; 11 pages.

6. BLIGNAUT M, LOOS B, BOTCHWAY SW, PARKER AW, HUISAMEN B. Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation. Scientific Reports 2019; 9(4782):s41598;11 pages.

7. BOOYSEN E, SADIE-VAN GIJSEN H, DEANE SM, FERRIS WF, DICKS LMT. The effect of Vancomycin on the Viability and Osteogenic Potential of Bone-Derived Mesenchymal Stem Cells. Probiotics and Antimicrobial Proteins 2019; 11:1009-1014.

8. BULABULA ANH, NELSON JA, MUSAFIRI EM, MACHEKANO R, SAM-AGUDU NA, DIACON AH, SHAH M, CRESWELL J, THERON GDV, WARREN RM, JACOBSON KR, CHIRAMBIZA JP, KALUMUNA D, BISIMWA B, KATOTO PDMC, GROBUSCH MP, NACHEGA JB, ET AL. Prevalence, Predictors, and Successful Treatment outcomes of expert mtb/rif-identified rifampicin-resistant tuberculosis in post-conflict eastern democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study. Clinical Infectious Diseases 2019; 69(8):1278-1287.

9. CHRISTOWITZ C, DAVIS TA, ISAACS AW, VAN NIEKERK G, HATTINGH SM, ENGELBRECHT AM. Mechanisms of doxorubicin-induced drug resistance and drug resistant tumor growth in a murine breast tumour model. BMC CANCER 2019; 19(757):s12885; 10 pages.

10. CILLIERS K, MULLER CJF, PAGE B. Human Immunodeficiency Virus in Cadavers: A Review. CLINICAL ANATOMY 2019; 32:603-610.

11. DE SMIDT JJA, ODENDAAL HJ, NEL DG, NOLAN H, DU PLESSIS CA, BRINK LT, OELOFSE A. In utero teratogen exposure and cardiometabolic risk in 5-year-old children: a prospective pediatric study. Journal of Maternal-Fetal and Neonatal Medicine 2019; 24:1-10.

12. DIAS SC, ADAM S, RHEEDER P, LOUW J, PHEIFFER C. Altered Genome-Wide DNA Methylation in Peripheral Blood of South African Women with Gestational Diabetes Mellitus. International Journal of Molecular Sciences 2019; 20:5828;17 pages.

13. DIAS SC, ADAM S, RHEEDER P, PHEIFFER C. Prevalence of and risk factors for gestational diabetes mellitus in South Africa. SAMJ South African Medical Journal 2019; 109(7):463-677.

14. DIAS SC, PHEIFFER C, RHEEDER P, ADAM S. Screening and diagnosis of gestational diabetes mellitus in South Africa: What do we know so far. SAMJ South African Medical Journal 2019; 109(7):457-462.

15. DLUDLA PV, ORLANDO P, SILVESTRI S, MAZIBUKO-MBEJE S, JOHNSON R, MARCHEGGIANI F, CIRILLI I, MULLER CJF, LOUW J, OBONYE NJ, NYAWO TA, ET AL (ENIGMA CONSORTIUM) C. N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q9/10 levels. Toxicology Reports 2019; 6:1240-1245.

16. DRIESCHER N, JOSEPH DE, HUMAN VR, OJUKA E, COUR M, HADEBE N, BESTER DJ, MARNEWICK JL, LECOUR S, LOCHNER A, ESSOP MF. The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 2019; 5:e01357; 28 pages.

17. DUBE KR, KARTHIK D, SALIE R, BLIGNAUT M, HUISAMEN B, LOCHNER A. Melatonin has profound effects on mitochondrial dynamics in myocardial ischaemia/reperfusion. Heliyon 2019; 5:e02659;19 pages.

18. Everson FP, DE BOEVER P, NAWROT TS, GOSWAMI N, MTHETHWA M, WEBSTER I, MARTENS DS, MASHELE N, CHARANIA S, KAMAU F, STRIJDOM JG. Personal NO2 and Volatile Organic Compounds Exposure Levels are Associated with Markers of Cardiovascular Risk in Women in the Cape Town Region of South Africa. International Journal of Environmental Research and Public Health 2019; 16:2284; 18 pages.

19. FRIEDRICH SO, KOLWIJCK E, KARINJA MN, VAN DER MERWE L, DIACON AH. Quantification of viable bacterial load in artificial sputum spiked with Mycobacterium tuberculosis. Tuberculosis 2019; 115:140-145.

20. GOSS DM, AYAD BM, VAN DER HORST G, SKOSANA BT, DU PLESSIS SS. Improved sperm motility after 4h of ejaculatory abstinence: role of accessory sex gland secretions. Reproduction, Fertility and Development 2019; 31(5):1009-1016.

21. HUANG SH, TSENG JC, LIN CY, KUO YY, WANG BJ, KAO YH, MULLER CJF, JOUBERT E, CHUU CP. Rooibos suppresses profileration of castration-resistant prostate cancer cells via inhibition of AKt signaling. PHYTOMEDICINE 2019; 64(0944-7113):1-10.

23. JACK BU, MALHERBE CJ, MAMUSHI MP, MULLER CJF, JOUBERT E, LOUW J, PHEIFFER C. Adipose tissue as a possible therapeutic target for polyphenols: a case for Cyclopia extracts as anti-abesity nutraceuticals. Biomedicine and Pharmacotherapy 2019; 120(0753-3322):0.

24. JOHNSON R, DLUDLA PV, MABHIDA SE, BENJEDDOU M, LOUW J, FEBRUARY MF. Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review. HEART FAILURE REVIEWS 2019; 24:343-357.

25. JOHNSON R, SANGWENI NF, MABHIDA SE, DLUDLA PV, MABASA L, RIEDEL-VAN HEERDEN SC, CHAPMAN C, MOSA RA, KAPPO AP, LOUW J, MULLER CJF. An In Vitro Study on the Combination Effect of Metformin and N-Acetyl Cysteine against Hyperglycaemia-Induced Cardiac Damage. Nutrients 2019; 11:2850;19 pages.

26.  F, STRIJDOM JG, MWANGI P, BLACKHURST D, IMPERIAL EG, SALIE R. Antiretroviral drug-induced endothelial dysfunction is improved by dual PPAR alpha/gamma stimulation in obesity. VASCULAR PHARMACOLOGY 2019; 121:106577; 11 pages.

27. KARTHIK D, HUISAMEN B, LOCHNER A. Mitochondrial oxidative phosphorylation and mitophagy in myocardial ischaemia/reperfusion: effects of chloroquine. Cardiovascular Journal of Africa 2019; 30:067; 11 pages.

28. KATOTO PDMC, BYAMUNGU L, BRAND AS, MOKAYA J, STRIJDOM JG, GOSWAMI N, DE BOEVER P, NAWROT TS, NEMERY B. Ambient air pollution and health in Sub-Saharan Africa: Current evidence, perspectives and a call to action. Environmental Research 2019; 173(July 2019):1-31.

29. LAYMAN J, PEREIRA DL, CHELLAN N, HUISAMEN B, KOTZE SH. A histomorphometric study on the hepatoprotective effects of a green rooibos extract in a diet-induced obese rat model. Acta Histochemica 2019; 121:646-656.

30. LOURENS M, PHILIPS L, KLEINHANS C, FRIEDRICH SO, MARTINSON N, VENTER A, VAN DER MERWE L, DIACON AH. Liquid mycobacterial culture outcomes after different sputum collection techniques before and during treatment. Tuberculosis 2019; 116:17-21.

31. MAARMAN GJ. Cardioprotection conferred by rooibos (Aspalathus linearis): A mini review to highlight a potential mechanism of action. South African Journal of Science 2019; 115(7/8):4653, 4 pages.

32. MABASA L, SAMODIEN E, SANGWENI NF, PHEIFFER C, LOUW J, JOHNSON R. In Utero One-Carbon Metabolism Interplay and Metabolic Syndrome in Cardiovascular Disease Risk Reduction. Molecular Nutrition and Food Research 2019; 13:e1900377; 11 pages.

33. MABHIDA SE, JOHNSON R, NDLOVU M, LOUW J, OPOKU AR, MOSA RA. Molecular basis of the anti-hyperglycemic activity of RA-3 in hyperlipidemic and streptozotocin-induced type 2 diabetes in rats. Diabetology and Metabolic Syndrome 2019; 11(27):s13098; 5 pages.

34. MARINCOWITZ MEC, GENIS A, GOSWAMI N, DE BOEVER P, NAWROT TS, STRIJDOM JG. Vascular endothelial dysfunction in the wake of HIV and ART. FEBS Journal 2019; 286:1256-1270.

35. MAZIBUKO SE, DLUDLA PV, JOHNSON R, JOUBERT E, LOUW J, ZIQUBU K, TIANO L, SILVESTRI S, ORLANDO P, OPOKU AR, MULLER CJF. Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration. PLoS One 2019; 14(5):e0216172;16pages.

36. MAZIBUKO SE, DLUDLA PV, ROUX C, JOHNSON R, GHOOR S, JOUBERT E, LOUW J, OPOKU AR, MULLER CJF. Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways. International Journal of Molecular Sciences 2019; 20:633; 16 pages.

37. NIESLER CU, VAN DE VYVER M, MYBURGH KH. Cellular regenerative therapy for acquired non-congenital musculoskeletal disorders. SAMJ South African Medical Journal 2019; 109(8):59-64.

38. ORLANDO P, CHELLAN N, LOUW J, TIANO L, CIRILLI I, DLUDLA PV, JOUBERT E, MULLER CJF. Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholestrol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys. Molecules 2019; 24:0.

39. PATEL O, MULLER CJF, JOUBERT E, ROSENKRANZ BF, TAYLOR MJC, LOUW J, AWORTWE C. Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats. Frontiers in Pharmacology 2019; 10:doi: 10.3389/fphar.2019.01243 (1-8).

40. PHEIFFER C, DIAS SC, RHEEDER P, ADAM S. MicroRNA Profiling in HIV-Infected South African Women with Gestational Diabetes Mellitus. Molecular Diagnosis & Therapy 2019; 23:499-505.

41. RODGERS AL, JAPPIE-MAHOMED D, VAN JAARSVELD PJ. Testing the dogma that total phospholipid fatty acid composition of blood plays a role in kidney stone pathogenesis, using a high-low risk human model: results from a pilot study. Urolithiasis 2019; 47:255-261.

42. SADIE-VAN GIJSEN H. Adipocyte biology: it is time to upgrade to a new model. JOURNAL OF CELLULAR PHYSIOLOGY 2019; 234:2399-2425.

43. SADIE-VAN GIJSEN H. The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications. Current Osteoporosis Reports 2019; 17:405-415.

44. SALIE R, ALSALHIN AKH, MARAIS E, LOCHNER A. Cardioprotective Effects of Beta3-Adrenergic Receptor (Beta3-AR) Pre-, Per-, and Post -treatment in Ischemia-Reperfusion. Cardiovascular Drugs and Therapy 2019; 33:163-177.

45. SAMODIEN E, JOHNSON R, PHEIFFER C, MABASA L, ERASMUS M, LOUW J, CHELLAN N. Diet-induced hypothalamic dysfunction and metabolic disease and the therapeutic potential of polyphenols. Molecular Metabolism 2019; 27:s2212;10 pages.

46. SAMODIEN E, PHEIFFER C, ERASMUS M, MABASA L, LOUW J, JOHNSON R. Diet-induced DNA methylation within the hypothalamic arcuate nucleus and dysregulated leptin and insulin signalling in the pathophysiology of obesity. Food Science & Nutrition 2019; 7:3131-3145.

47. SANGWENI NF, DLUDLA PV, MOSA RA, KAPPO AP, OPOKU AR, MULLER CJF, JOHNSON R. Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review. HEART FAILURE REVIEWS 209; 24:155-166.

48. SHABALALA S, DLUDLA PV, MULLER CJF, NXELE X, KAPPO AP, LOUW J, JOHNSON R. Aspalathin ameliorates doxorubicin-induced oxidative stress in H9c2 cardiomyoblasts. Toxicology in Vitro 2019; 55:134-139.

49. SHAW JA, DIACON AH, KOEGELENBERG CFN. Tuberculosis pleural effusion. RESPIROLOGY 2019; 24:962-971.

50. SVENSSON EM, DU BOIS J, KITSHOFF R, DE JAGER V, WIESNER L, NORMAN J, NACHMAN S, SMITH B, DIACON AH, HESSELING AC, GARCIA-PRATS AJ. Relative bioavailability of bedaquiline tablets suspended in water: implications for dosing in children. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2019; 84:2384-2392.

51. TAIT DR, HATHERILL M, VAN DER MEEREN O, GINSBERG AM, VAN BRAKEL E, SALAUN B, SCRIBA TJ, AKITE EJ, AYLES H, DIACON AH, ET AL (ENIGMA CONSORTIUM) C. Final Analysis of a trial of M72/AS01E Vaccine to Prevent Tuberculosis. NEW ENGLAND JOURNAL OF MEDICINE 2019; 381(25):2429-2439.

52. TWEED CD, CROOK AM, DAWSON R, DIACON AH, MCHUGH TD, MENDEL CM, MEREDITH SK, MOHAPI L, MURPHY ME, ET AL (ENIGMA CONSORTIUM) C. Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status. BMC Pulmonary Medicine 2019; 19(152):s12890; 9 pages.

53. TWEED CD, DAWSON R, BURGER DA, CONRADIE A, CROOK AM, MENDEL CM, CONRADIE F, DIACON AH, NTINGINYA E, ET AL (ENIGMA CONSORTIUM) C. Bedaquiline, moxifloxacin, pretomanid and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial. Lancet Respiratory Medicine 2019; 7:1048-1058.

54. WARREN RM, ISMAIL N, CHEGOU NN, THERON GDV, WALZL G, MALHERBE ST, KINNEAR CJ, VAN DER SPUY GD, GOOSEN WJ, MILLER MA, DIACON AH, VAN HELDEN PD. Tuberculosis research in South Africa over the past 30 years: From bench to bedside. SAMJ South African Medical Journal 2019; 109(11):45-52.

55. WEBSTER I, IMPERIAL EG, WESTCOTT C, STRIJDOM JG. The cardiovascular effects of Aspalathus linearis supplementation in male Wistar rats receiving fixed-dose combination first-line antiretroviral therapy. Cardiovascular Journal of Africa 2019; 30(2):95-102.

Books

HUISAMEN B, VAN VUUREN MA, PHEIFFER C. Medicinal Effects of Agathosma (Buchu) Extracts. Aosis, Cape Town, South Africa 2019:108 pp.

Book Chapters

1. MAARMAN GJ. Molecular Nutrition Carbohydrates. Elsevier, 2019:442 pp.?

2. MAARMAN GJ. Oxidative Stress in Heart Disease. Springer, Singapore. 2019:596 pp.

2018

?Journal Articles

  1. ??Agarwal, A., Sharma, R., Henkel, R., Roychoudhury, S., Sikka, S.C., du Plessis, S., Sarda, Y.B., Speyer, C., Nouh, M., Douglas, C., Kayali, Z., Elshaer, A., Sabanegh, E., 2018. Cumene hydroperoxide induced changes in oxidation-reduction potential in fresh and frozen seminal ejaculates. Andrologia 50, e12796. https://doi.org/10.1111/and.12796?
  2. Aggerbeck, H., Ruhwald, M., Hoff, S.T., Borregaard, B., Hellstrom, E., Malahleha, M., Siebert, M., Gani, M., Seopela, V., Diacon, A., Lourens, M., Andersen, P., Dheda, K., 2018. C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial. PLoS One 13, e0204554. https://doi.org/10.1371/journal.pone.0204554
  3. Arokoyo, Dennis Seyi, Oyeyipo, I.P., Du Plessis, S.S., Aboua, Y.G., 2018. Antioxidant Activities of Basella alba Aqueous Leave Extract In Blood, Pancreas, and Gonadal Tissues of Diabetic Male Wistar Rats. Pharmacognosy Res. 10, 31–36. https://doi.org/10.4103/pr.pr_84_17
  4. Arokoyo, Dennis S, Oyeyipo, I.P., Du Plessis, S.S., Chegou, N.N., Aboua, Y.G., 2018. Modulation of Inflammatory Cytokines and Islet Morphology as Therapeutic Mechanisms of Basella alba in Streptozotocin-Induced Diabetic Rats. Toxicol. Res. 34, 325–332. https://doi.org/10.5487/TR.2018.34.4.325
  5. Augustine, T.N., Cairns, C.J., Chetty, S., Dannatt, L.G., Gravett, N., Grey, G., Grobler, G., Jafta, Z., Kamerman, P., Lopes, J., Matsabisa, M.G., Mugabo, P., Mulder, M., Parry, C., Rataemane, S., Siegfried, N., Steenkamp, V., Thomas, E., Van Zyl-Smit, R., 2018. Priority areas for cannabis and cannabinoid product research in South Africa. African J. Prim. Heal. Care Fam. Med. 10, 1–3. https://doi.org/10.4102/phcfm.v10i1.1711
  6. Ayad, Bashir M, Horst, G. Van der, Plessis, S.S. Du, 2018. Revisiting The Relationship between The Ejaculatory Abstinence Period and Semen Characteristics. Int. J. Fertil. Steril. 11, 238–246. https://doi.org/10.22074/ijfs.2018.5192
  7. Ayad, Bashir M., Van der Horst, G., du Plessis, S.S., 2018. Short abstinence: A potential strategy for the improvement of sperm quality. Middle East Fertil. Soc. J. 23, 37–43. https://doi.org/10.1016/J.MEFS.2017.07.005
  8. Cerf, M., 2018a. Cardiac Glucolipotoxicity and Cardiovascular Outcomes. Medicina (B. Aires). 54, 70. https://doi.org/10.3390/medicina54050070
  9. Cerf, M., 2018b. High Fat Programming and Cardiovascular Disease. Medicina (B. Aires). 54, 86. https://doi.org/10.3390/medicina54050086
  10. Chimhashu, T., Malan, L., Baumgartner, J., van Jaarsveld, P.J., Galetti, V., Moretti, D., Smuts, C.M., Zimmermann, M.B., 2018. Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children. Br. J. Nutr. 119, 610–619. https://doi.org/10.1017/S000711451700366X
  11. Dludla, P.V., Gabuza, K.B., Muller, C.J.F., Joubert, E., Low, J., Johnson, R., 2018. Aspalathin, a C-glucosyl Dihydrochalcone From Rooibos Improves the Hypoglycemic Potential of Metformin in Type 2 Diabetic (db/db) Mice. Physiol. Res. 67, 813–818.
  12. Dludla, Phiwayinkosi V., Dias, S.C., Obonye, N., Johnson, R., Louw, J., Nkambule, B.B., 2018a. A Systematic Review on the Protective Effect of N-Acetyl Cysteine Against Diabetes-Associated Cardiovascular Complications. Am. J. Cardiovasc. Drugs 18, 283–298. https://doi.org/10.1007/s40256-018-0275-2
  13. Dludla, Phiwayinkosi V., Jack, B., Viraragavan, A., Pheiffer, C., Johnson, R., Louw, J., Muller, C.J.F., 2018b. A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes. Toxicol. Reports 5, 1014–1020. https://doi.org/10.1016/J.TOXREP.2018.10.002
  14. Donald, P.R., Diacon, A.H., Lange, C., Demers, A.-M., von Groote-Biddlingmeier, F., Nardell, E., 2018. Droplets, dust and guinea pigs: an historical review of tuberculosis transmission research, 1878–1940. Int. J. Tuberc. Lung Dis. 22, 972–982. https://doi.org/10.5588/ijtld.18.0173
  15. Everson, F., Genis, A., Ogundipe, T., Boever, P. De, Goswami, N., Lochner, A., Blackhurst, D., Id, H.S., 2018. Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir , emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats 1–27. https://doi.org/10.1371/journal.pone.0208537
  16. Goedecke, J.H., Mendham, A.E., Clamp, L., Nono Nankam, P.A., Fortuin-de Smidt, M.C., Phiri, L., Micklesfield, L.K., Keswell, D., Woudberg, N.J., Lecour, S., Alhamud, A., Kaba, M., Lutomia, F.M., van Jaarsveld, P.J., de Villiers, A., Kahn, S.E., Chorell, E., Hauksson, J., Olsson, T., 2018. An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants. JMIR Res. Protoc. 7, e75. https://doi.org/10.2196/resprot.9098
  17. Govender, J., Loos, B., Marais, E., Engelbrecht, A.-M., 2018. Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? Toxicol. Appl. Pharmacol. 358, 86–101. https://doi.org/10.1016/J.TAAP.2018.06.031
  18. Govindsamy, A., Naidoo, S., Cerf, M.E., 2018. Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease. J. Nutr. Metab. 2018, 1–12. https://doi.org/10.1155/2018/8547976
  19. Jack, B., Malherbe, C., Willenburg, E., de Beer, D., Huisamen, B., Joubert, E., Muller, C., Louw, J., Pheiffer, C., 2018. Polyphenol-Enriched Fractions of Cyclopia intermedia Selectively Affect Lipogenesis and Lipolysis in 3T3-L1 Adipocytes. Planta Med. 84, 100–110. https://doi.org/10.1055/s-0043-119463
  20. Johnson, R., Beer, D. de, Dludla, P., Ferreira, D., Muller, C., Joubert, E., 2018. Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome. Planta Med. 84, 568–583. https://doi.org/10.1055/s-0044-100622
  21. Kruger, M.J., Conradie, M.M., Conradie, M., Van De Vyver, M., 2018. ADSC-conditioned media elicit an ex vivo anti-inflammatory macrophage response. J. Mol. Endocrinol. 61, 173–184. https://doi.org/10.1530/JME-18-0078
  22. Lange, C., Alghamdi, W.A., Al-Shaer, M.H., Brighenti, S., Diacon, A.H., DiNardo, A.R., Grobbel, H.P., Gr?schel, M.I., von Groote-Bidlingmaier, F., Hauptmann, M., Heyckendorf, J., K?hler, N., Kohl, T.A., Merker, M., Niemann, S., Peloquin, C.A., Reimann, M., Schaible, U.E., Schaub, D., Schleusener, V., Thye, T., Sch?n, T., 2018. Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis. J. Intern. Med. 284, 163–188. https://doi.org/10.1111/joim.12780
  23. Levine, H., Mohri, H., Ekbom, A., Ramos, L., Parker, G., Roldan, E., Jovine, L., Koelle, S., Lindstrand, A., Immler, S., Mortimer, S., Mortimer, D., van der Horst, G., Ishijima, S., Aneck-Hahn, N., Baldi, E., Menkveld, R., Rothmann, S.A., Giwercman, A., Giwercman, Y., Holmberg, M., Kvist, U., Bj?rndahl, L., Holmberg, R., Arver, S., Flanagan, J., Drevet, J.R., 2018. Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th–12th 2018, Stockholm, Sweden. Basic Clin. Androl. 28, 13. https://doi.org/10.1186/s12610-018-0077-z
  24. Lochner, A., Marais, E., Huisamen, B., 2018. Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review. J. Pineal Res. 65, e12490. https://doi.org/10.1111/jpi.12490
  25. Lumkwana, D., Botha, A., Samodien, E., Hanser, S., Lopes, J., 2017. Laminin, laminin-entactin and extracellular matrix are equally appropriate adhesive substrates for isolated adult rat cardiomyocyte culture and experimentation. Cell Adh. Migr. 1–9. https://doi.org/10.1080/19336918.2017.1387693
  26. Mabhida, Sihle E., Dludla, P. V., Johnson, R., Ndlovu, M., Louw, J., Opoku, A.R., Mosa, R.A., 2018. Protective effect of triterpenes against diabetes-induced β-cell damage: An overview of in vitro and in vivo studies. Pharmacol. Res. 137, 179–192. https://doi.org/10.1016/J.PHRS.2018.10.004
  27. Mabhida, Sihle Ephraim, Johnson, R., Ndlovu, M., Sangweni, N.F., Louw, J., Opoku, A., Mosa, R.A., 2018. A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats. BMC Complement. Altern. Med. 18, 265. https://doi.org/10.1186/s12906-018-2337-z
  28. Mehrbani Azar, Y., Green, R., Niesler, C.U., van de Vyver, M., 2018. Antioxidant Preconditioning Improves the Paracrine Responsiveness of Mouse Bone Marrow Mesenchymal Stem Cells to Diabetic Wound Fluid. Stem Cells Dev. 27, 1646–1657. https://doi.org/10.1089/scd.2018.0145
  29. Mentoor, I., Engelbrecht, A.-M., van Jaarsveld, P.J., Nell, T., 2018. Chemoresistance: Intricate Interplay Between Breast Tumor Cells and Adipocytes in the Tumor Microenvironment. Front. Endocrinol. (Lausanne). 9, 758. https://doi.org/10.3389/fendo.2018.00758
  30. Mondloch, S.J., Tanumihardjo, S.A., Davis, C.R., van Jaarsveld, P.J., 2018. Hepatic Vitamin A Concentrations in Vervets ( Chlorocebus aethiops ) Supplemented with Carotenoids Derived from Oil Palm. J. Am. Assoc. Lab. Anim. Sci. 57, 456–464. https://doi.org/10.30802/AALAS-JAALAS-17-000148
  31. Murakami, S., Miura, Y., Hattori, M., Matsuda, H., Malherbe, C., Muller, C., Joubert, E., Yoshida, T., 2018. Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture. Planta Med. 84, 311–319. https://doi.org/10.1055/s-0043-121270
  32. Omolaoye, T.S., Skosana, B.T., du Plessis, S.S., 2018. Diabetes mellitus- induction: Effect of different streptozotocin doses on male reproductive parameters. Acta Histochem. 120, 103–109. https://doi.org/10.1016/J.ACTHIS.2017.12.005
  33. Ordoqui, R., Barrera, N., Montes, J.M., Canepa, M., Bonelli, C., Surka, C., Torrens, A., Cantú, L., Plessis, S.S. du, 2018. A retrospective study on sperm banking: a Uruguayan experience. JBRA Assist. Reprod. 22, 82–88. https://doi.org/10.5935/1518-0557.20180037
  34. Oyeyipo, I.P., Skosana, B.T., Everson, F.P., Strijdom, H., du Plessis, S.S., 2018. Highly Active Antiretroviral Therapy Alters Sperm Parameters and Testicular Antioxidant Status in Diet-Induced Obese Rats. Toxicol. Res. 34, 41–48. https://doi.org/10.5487/TR.2018.34.1.041
  35. Peloquin, C.A., Phillips, P.P.J., Mitnick, C.D., Eisenach, K., Patientia, R.F., Lecca, L., Gotuzzo, E., Gandhi, N.R., Butler, D., Diacon, A.H., Martel, B., Santillan, J., Hunt, K.R., Vargas, D., von Groote-Bidlingmaier, F., Seas, C., Dianis, N., Moreno-Martinez, A., Kaur, P., Horsburgh, C.R., 2018. Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis. Antimicrob. Agents Chemother. 62. https://doi.org/10.1128/AAC.00770-18
  36. Pheiffer, C., Pillay-van Wyk, V., Joubert, J.D., Levitt, N., Nglazi, M.D., Bradshaw, D., 2018. The prevalence of type 2 diabetes in South Africa: a systematic review protocol. BMJ Open 8, e021029. https://doi.org/10.1136/bmjopen-2017-021029
  37. Puerta Suárez, J., du Plessis, S.S., Cardona Maya, W.D., 2018. Spermatozoa: A Historical Perspective. Int. J. Fertil. Steril. 12, 182–190. https://doi.org/10.22074/ijfs.2018.5316
  38. Shaw, J.A., Irusen, E.M., Diacon, A.H., Koegelenberg, C.F., 2018. Pleural tuberculosis: A concise clinical review. Clin. Respir. J. 12, 1779–1786. https://doi.org/10.1111/crj.12900
  39. Smit, S., Johnson, R., Van Vuuren, M., Huisamen, B., 2018. Myocardial Glucose Clearance by Aspalathin Treatment in Young, Mature, and Obese Insulin-Resistant Rats. Planta Med. 84, 75–82. https://doi.org/10.1055/s-0043-117415
  40. Svensson, Elin M., du Bois, J., Kitshoff, R., de Jager, V.R., Wiesner, L., Norman, J., Nachman, S., Smith, B., Diacon, A.H., Hesseling, A.C., Garcia-Prats, A.J., 2018. Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children. Br. J. Clin. Pharmacol. 84, 2384–2392. https://doi.org/10.1111/bcp.13696
  41. Svensson, Elin M, Svensson, R.J., te Brake, L.H.M., Boeree, M.J., Heinrich, N., Konsten, S., Churchyard, G., Dawson, R., Diacon, A.H., Kibiki, G.S., Minja, L.T., Ntingiya, N.E., Sanne, I., Gillespie, S.H., Hoelscher, M., Phillips, P.P.J., Simonsson, U.S.H., Aarnoutse, R., 2018. The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis. Clin. Infect. Dis. 67, 34–41. https://doi.org/10.1093/cid/ciy026
  42. Svensson, R.J., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Boeree, M.J., Simonsson, U.S.H., 2018. A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses. Clin. Pharmacol. Ther. 103, 674–683. https://doi.org/10.1002/cpt.778
  43. Svensson, R.J., Svensson, E.M., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Moodley, M., Boeree, M.J., Simonsson, U.S.H., 2018. Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations. J. Infect. Dis. 218, 991–999. https://doi.org/10.1093/infdis/jiy242
  44. Temidayo, So., Stefan, S.P., 2018. Diabetes mellitus and male infertility. Asian Pacific J. Reprod. 7, 6. https://doi.org/10.4103/2305-0500.220978
  45. Thomas, M., Davis, T., Loos, B., Sishi, B., Huisamen, B., Strijdom, H., Engelbrecht, A.-M., 2018. Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells. Cell Biochem. Funct. 36, 65–79. https://doi.org/10.1002/cbf.3318
  46. Truter, D., Chellan, N., Strijdom, H., Webster, I., Rawstorne, J., Kotzé, S.H., 2018. Histomorphological changes in the pancreas and kidney and histopathological changes in the liver in male Wistar rats on antiretroviral therapy and melatonin treatment. Acta Histochem. 120, 347–355. https://doi.org/10.1016/J.ACTHIS.2018.03.006
  47. Tweed, Conor D., Crook, A.M., Amukoye, E.I., Dawson, R., Diacon, A.H., Hanekom, M., McHugh, T.D., Mendel, C.M., Meredith, S.K., Murphy, M.E., Murthy, S.E., Nunn, A.J., Phillips, P.P.J., Singh, K.P., Spigelman, M., Wills, G.H., Gillespie, S.H., 2018. Toxicity associated with tuberculosis chemotherapy in the REMoxTB study. BMC Infect. Dis. 18, 317. https://doi.org/10.1186/s12879-018-3230-6
  48. Tweed, Conor Duncan, Wills, G.H., Crook, A.M., Dawson, R., Diacon, A.H., Louw, C.E., McHugh, T.D., Mendel, C., Meredith, S., Mohapi, L., Murphy, M.E., Murray, S., Murthy, S., Nunn, A.J., Phillips, P.P.J., Singh, K., Spigelman, M., Gillespie, S.H., 2018. Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study. BMC Med. 16, 46. https://doi.org/10.1186/s12916-018-1033-7
  49. van der Horst, G., Maree, L., du Plessis, S.S., 2018. Current perspectives of CASA applications in diverse mammalian spermatozoa. Reprod. Fertil. Dev. 30, 875. https://doi.org/10.1071/RD17468
  50. Van Der Meeren, O., Hatherill, M., Nduba, V., Wilkinson, R.J., Muyoyeta, M., Van Brakel, E., Ayles, H.M., Henostroza, G., Thienemann, F., Scriba, T.J., Diacon, A., Blatner, G.L., Demoitié, M.-A., Tameris, M., Malahleha, M., Innes, J.C., Hellstr?m, E., Martinson, N., Singh, T., Akite, E.J., Khatoon Azam, A., Bollaerts, A., Ginsberg, A.M., Evans, T.G., Gillard, P., Tait, D.R., 2018. Phase 2b Controlled Trial of M72/AS01 E Vaccine to Prevent Tuberculosis. N. Engl. J. Med. 379, 1621–1634. https://doi.org/10.1056/NEJMoa1803484
  51. Willmer, T., Johnson, R., Louw, J., Pheiffer, C., 2018. Blood-Based DNA Methylation Biomarkers for Type 2 Diabetes: Potential for Clinical Applications. Front. Endocrinol. (Lausanne). 9, 744. https://doi.org/10.3389/fendo.2018.00744?

2017

Journal Articles?

  1. Alsultan, A., Furin, J.J., Du Bois, J., van Brakel, E., Chheng, P., Venter, A., Thiel, B., Debanne, S.A., Boom, W.H., Diacon, A.H., Johnson, J.L., Peloquin, C.A., 2017. Population Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 61. https://doi.org/10.1128/AAC.01066-17

  2. Ayad, B.M., Horst, G. Van der, Plessis, S.S. Du, 2018. Revisiting The Relationship between The Ejaculatory Abstinence Period and Semen Characteristics. Int. J. Fertil. Steril. 11, 238–246. https://doi.org/10.22074/ijfs.2018.5192

  3. Boeree, M.J., Heinrich, N., Aarnoutse, R., Diacon, A.H., Dawson, R., Rehal, S., Kibiki, G.S., Churchyard, G., Sanne, I., Ntinginya, N.E., Minja, L.T., Hunt, R.D., Charalambous, S., Hanekom, M., Semvua, H.H., Mpagama, S.G., Manyama, C., Mtafya, B., Reither, K., Wallis, R.S., Venter, A., Narunsky, K., Mekota, A., Henne, S., Colbers, A., van Balen, G.P., Gillespie, S.H., Phillips, P.P.J., Hoelscher, M., 2017. High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial. Lancet Infect. Dis. 17, 39–49. https://doi.org/10.1016/S1473-3099(16)30274-2
  4. Bouton, T.C., Phillips, P.P.J., Mitnick, C.D., Peloquin, C.A., Eisenach, K., Patientia, R.F., Lecca, L., Gotuzzo, E., Gandhi, N.R., Butler, D., Diacon, A.H., Martel, B., Santillan, J., Hunt, K.R., Vargas, D., von Groote-Bidlingmaier, F., Seas, C., Dianis, N., Moreno-Martinez, A., Horsburgh, C.R., 2017. An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens: study protocol for a randomized controlled trial. Trials 18, 563. https://doi.org/10.1186/s13063-017-2292-x
  5. Bowles, S., Joubert, E., de Beer, D., Louw, J., Brunschwig, C., Njoroge, M., Lawrence, N., Wiesner, L., Chibale, K., Muller, C., 2017. Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin. Molecules 22, 554. https://doi.org/10.3390/molecules22040554
  6. De Jager, V., van der Merwe, L., Venter, A., Donald, P.R., Diacon, A.H., 2017. Time Trends in Sputum Mycobacterial Load and Two-Day Bactericidal Activity of Isoniazid-Containing Antituberculosis Therapies. Antimicrob. Agents Chemother. 61. https://doi.org/10.1128/AAC.02088-16
  7. Dludla, P., Muller, C., Joubert, E., Louw, J., Essop, M., Gabuza, K., Ghoor, S., Huisamen, B., Johnson, R., 2017. Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression. Molecules 22, 129. https://doi.org/10.3390/molecules22010129
  8. Dludla, P. V., Essop, M.F., Gabuza, K.B., Muller, C.J.F., Louw, J., Johnson, R., 2017a. Age-dependent development of left ventricular wall thickness in type 2 diabetic (db/db) mice is associated with elevated low-density lipoprotein and triglyceride serum levels. Heart Vessels 32, 1025–1031. https://doi.org/10.1007/s00380-017-0978-3
  9. Dludla, P. V., Joubert, E., Muller, C.J.F., Louw, J., Johnson, R., 2017b. Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside. Nutr. Metab. (Lond). 14, 45. https://doi.org/10.1186/s12986-017-0200-8
  10. Dludla, P. V., Nkambule, B.B., Dias, S.C., Johnson, R., 2017c. Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage: a protocol for a systematic review. Syst. Rev. 6, 96. https://doi.org/10.1186/s13643-017-0493-8
  11. Jack, B.U., Malherbe, C.J., Huisamen, B., Gabuza, K., Mazibuko-Mbeje, S., Schulze, A.E., Joubert, E., Muller, C.J.F., Louw, J., Pheiffer, C., 2017. A polyphenol-enriched fraction of Cyclopia intermedia decreases lipid content in 3T3-L1 adipocytes and reduces body weight gain of obese db/db mice. South African J. Bot. 110, 216–229. https://doi.org/10.1016/J.SAJB.2016.08.007
  12. Johnson, R., Dludla, P., Muller, C., Huisamen, B., Essop, M., Louw, J., 2017a. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules 22, 219. https://doi.org/10.3390/molecules22020219
  13. Johnson, R., Shabalala, S., Louw, J., Kappo, A., Muller, C., 2017b. Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling. Molecules 22, 1589. https://doi.org/10.3390/molecules22101589
  14. Kayigire, X.A., Friedrich, S.O., van der Merwe, L., Diacon, A.H., 2017. Acquisition of Rifampin Resistance in Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 61. https://doi.org/10.1128/AAC.02220-16
  15. Kistan, J., Laher, F., Otwombe, K., Panchia, R., Mawaka, N., Lebina, L., Diacon, A., Kana, B., Martinson, N., 2017. Pulmonary TB: varying radiological presentations in individuals with HIV in Soweto, South Africa. Trans. R. Soc. Trop. Med. Hyg. 111, 132–136. https://doi.org/10.1093/trstmh/trx028
  16. Lalinde-Acevedo, P.C., Mayorga-Torres, B.J.M., Agarwal, A., du Plessis, S.S., Ahmad, G., Cadavid, ?.P., Cardona Maya, W.D., 2017. Physically Active Men Show Better Semen Parameters than Their Sedentary Counterparts. Int. J. Fertil. Steril. 11, 156–165. https://doi.org/10.22074/ijfs.2017.4881
  17. Nduhirabandi, F., Huisamen, B., Strijdom, H., Lochner, A., Barbara, H., 2017. Role of melatonin in glucose uptake by cardiomyocytes from insulin-resistant Wistar rats. Cardiovasc. J. Afr. 28, 362–369. https://doi.org/10.5830/CVJA-2017-018
  18. Nel, S., Strijdom, H., Genis, A., Everson, F., Van Wijk, R., Kotzé, S.H., 2017. A histomorphometric study on the effects of antiretroviral therapy (ART) combined with a high-calorie diet (HCD) on aortic perivascular adipose tissue (PVAT). Acta Histochem. 119, 555–562. https://doi.org/10.1016/J.ACTHIS.2017.05.009
  19. Oyeyipo, I.P., van der Linde, M., du Plessis, S.S., 2017. Environmental Exposure of Sperm Sex-Chromosomes: A Gender Selection Technique. Toxicol. Res. 33, 315–323. https://doi.org/10.5487/TR.2017.33.4.315
  20. Patten, V., Chabaesele, I., Sishi, B., Van Vuuren, D., 2017. Cardiomyocyte differentiation: Experience and observations from 2 laboratories. SA Hear. 14, 96–107. https://doi.org/10.24170/14-2-2498
  21. Salie, R., Lochner, A., Loubser, D.J., 2017. The significance of the washout period in preconditioning. Cardiovasc. Ther. 35, e12252. https://doi.org/10.1111/1755-5922.12252
  22. Shabalala, S., Muller, C.J.F., Louw, J., Johnson, R., 2017. Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life Sci. 180, 160–170. https://doi.org/10.1016/J.LFS.2017.05.003
  23. Strijdom, H., De Boever, P., Walzl, G., Essop, M.F., Nawrot, T.S., Webster, I., Westcott, C., Mashele, N., Everson, F., Malherbe, S.T., Stanley, K., Kessler, H.H., Stelzl, E., Goswami, N., 2017. Cardiovascular risk and endothelial function in people living with HIV/AIDS: Design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa. BMC Infect. Dis. 17, 1–9. https://doi.org/10.1186/s12879-016-2158-y
  24. Svensson, R.J., Aarnoutse, R.E., Diacon, A.H., Dawson, R., Gillespie, S.H., Boeree, M.J., Simonsson, U.S.H., 2017. A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses. Clin. Pharmacol. Ther. 103, 674–683. https://doi.org/10.1002/cpt.778
  25. Truter, D., Strijdom, H., Everson, F., Kotzé, S.H., 2017. Mucin secreting cells in the stomach and colon are altered by combination antiretroviral treatment in an obese rat model. Acta Histochem. 119, 122–128. https://doi.org/10.1016/J.ACTHIS.2016.11.014
  26. van Niekerk, G., Davids, L.M., Hattingh, S.M., Engelbrecht, A.-M., 2017. Cancer stem cells: A product of clonal evolution? Int. J. Cancer 140, 993–999. https://doi.org/10.1002/ijc.30448
  27. Walters, E., Demers, A.-M., van der Zalm, M.M., Whitelaw, A., Palmer, M., Bosch, C., Draper, H.R., Gie, R.P., Hesseling, A.C., 2017. Stool Culture for Diagnosis of Pulmonary Tuberculosis in Children. J. Clin. Microbiol. 55, 3355–3365. https://doi.org/10.1128/JCM.00801-17
  28. Webster, I., Salie, R., Marais, E., Fan, W.-J., Maarman, G., Huisamen, B., Lochner, A., 2017. Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age. BMC Physiol. 17, 3. https://doi.org/10.1186/s12899-017-0030-y
  29. Webster, Ingrid, Smith, A., Lochner, A., Huisamen, B., 2017. The Role of MKP-1 in Insulin-Induced Cardioprotection. Cardiovasc. Drugs Ther. 31, 247–254. https://doi.org/10.1007/s10557-017-6731-4
  30. Westcott, C., Genis, A., Mthethwa, M., Graham, R., Van Vuuren, D., Huisamen, B., Strijdom, H., 2017. Fenofibrate protects endothelial cells against the harmful effects of TNF-alpha. SAHeart 14, 22–34. https://doi.org/10.24170/14-1-1865?

?2016

?Journal Articles?

  1. Agarwal, A., Gupta, S., Du Plessis, S., Sharma, R., Esteves, S.C., Cirenza, C., Eliwa, J., Al-Najjar, W., Kumaresan, D., Haroun, N., Philby, S., Sabanegh, E., 2016a. Abstinence Time and Its Impact on Basic and Advanced Semen Parameters. Urology 94, 102–110. https://doi.org/10.1016/J.UROLOGY.2016.03.059
  2. Agarwal, A., Sharma, R., Roychoudhury, S., Du Plessis, S., Sabanegh, E., 2016b. MiOXSYS: a novel method of measuring oxidation reduction potential in semen and seminal plasma. Fertil. Steril. 106, 566-573.e10. https://doi.org/10.1016/J.FERTNSTERT.2016.05.013
  3. Bernasconi, M., Diacon, A.H., Koegelenberg, C.F.N., 2016. Stair Climbing Test Streamlines the Evaluation of Nonmalignant Lung Resection Candidates. Respiration 91, 87–88. https://doi.org/10.1159/000442889
  4. Demers, A.-M., Venter, A., Friedrich, S.O., Rojas-Ponce, G., Mapamba, D., Jugheli, L., Sasamalo, M., Almeida, D., Dorasamy, A., Jentsch, U., Gibson, M., Everitt, D., Eisenach, K.D., Diacon, A.H., 2016. Direct Susceptibility Testing of Mycobacterium tuberculosis for Pyrazinamide by Use of the Bactec MGIT 960 System. J. Clin. Microbiol. 54, 1276–81. https://doi.org/10.1128/JCM.03162-15
  5. Dludla, P., Muller, C., Joubert, E., Louw, J., Gabuza, K., Huisamen, B., Essop, M., Johnson, R., 2016. Phenylpyruvic Acid-2-O-β-D-Glucoside Attenuates High Glucose-Induced Apoptosis in H9c2 Cardiomyocytes. Planta Med. 82, 1468–1474. https://doi.org/10.1055/s-0042-110856
  6. Franzen, D., Diacon, A.H., Freitag, L., Schubert, P.T., Wright, C.A., Schuurmans, M.M., 2016. Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis: a randomised pilot trial. BMC Pulm. Med. 16, 62. https://doi.org/10.1186/s12890-016-0225-1
  7. Furin, J., Alirol, E., Allen, E., Fielding, K., Merle, C., Abubakar, I., Andersen, J., Davies, G., Dheda, K., Diacon, A., Dooley, K.E., Dravnice, G., Eisenach, K., Everitt, D., Ferstenberg, D., Goolam-Mahomed, A., Grobusch, M.P., Gupta, R., Harausz, E., Harrington, M., Horsburgh, C.R., Lienhardt, C., McNeeley, D., Mitnick, C.D., Nachman, S., Nahid, P., Nunn, A.J., Phillips, P., Rodriguez, C., Shah, S., Wells, C., Thomas-Nyang'wa, B., du Cros, P., 2016. Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults. Int. J. Tuberc. Lung Dis. 20, 290–294. https://doi.org/10.5588/ijtld.15.0490
  8. Furin, J.J., Du Bois, J., van Brakel, E., Chheng, P., Venter, A., Peloquin, C.A., Alsultan, A., Thiel, B.A., Debanne, S.M., Boom, W.H., Diacon, A.H., Johnson, J.L., 2016. Early Bactericidal Activity of AZD5847 in Patients with Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 60, 6591–6599. https://doi.org/10.1128/AAC.01163-16
  9. Goss, D., Oyeyipo, I.P., Skosana, B.T., Ayad, B.M., du Plessis, S.S., 2016. Ameliorative potentials of quercetin against cotinine-induced toxic effects on human spermatozoa. Asian Pacific J. Reprod. 5, 193–197. https://doi.org/10.1016/J.APJR.2016.03.005
  10. Huisamen, B., George, C., Genade, S., Dietrich, D., 2016a. Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes. South African J. Diabetes Vasc. Dis. 13, 61–67.
  11. Huisamen, B., Hafver, T.L., Lumkwana, D., Lochner, A., 2016b. The Impact of Chronic Glycogen Synthase Kinase-3 Inhibition on Remodeling of Normal and Pre-Diabetic Rat Hearts. Cardiovasc. Drugs Ther. 30, 237–246. https://doi.org/10.1007/s10557-016-6665-2
  12. Jayakumar, A., Savic, R.M., Everett, C.K., Benator, D., Alland, D., Heilig, C.M., Weiner, M., Friedrich, S.O., Martinson, N.A., Kerrigan, A., Zamudio, C., Goldberg, S. V, Whitworth, W.C., Davis, J.L., Nahid, P., 2016. Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure. J. Clin. Microbiol. 54, 3028–3033. https://doi.org/10.1128/JCM.01313-16
  13. Johnson, R., Dludla, P., Joubert, E., February, F., Mazibuko, S., Ghoor, S., Muller, C., Louw, J., 2016. Aspalathin, a dihydrochalcone C -glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis. Mol. Nutr. Food Res. 60, 922–934. https://doi.org/10.1002/mnfr.201500656
  14. Jordaan, A.E., 2016. The effects of the wild african potato (hypoxis hemerocallidea) supplementation on streptozotocin-induced diabetic wistar rats reproductive function. Andrology 5, 1000165.
  15. Kayigire, X.A., Friedrich, S.O., Karinja, M.N., van der Merwe, L., Martinson, N.A., Diacon, A.H., 2016. Propidium monoazide and Xpert MTB/RIF to quantify Mycobacterium tuberculosis cells. Tuberculosis 101, 79–84. https://doi.org/10.1016/J.TUBE.2016.08.006
  16. Lückhoff, H.K., Kidd, M., van Rensburg, S.J., van Velden, D.P., Kotze, M.J., 2016. Apolipoprotein E genotyping and questionnaire-based assessment of lifestyle risk factors in dyslipidemic patients with a family history of Alzheimer's disease: test development for clinical application. Metab. Brain Dis. 31, 213–224. https://doi.org/10.1007/s11011-015-9737-2
  17. Mfokazi, A., Wright, C.A., Louw, M., Von Groote-Bidlingmaier, F., Schubert, P.T., Koegelenberg, C.F.N., Diacon, A.H., 2016. Direct comparison of liquid-based and smear-based cytology with and without rapid on-site evaluation for fine needle aspirates of thoracic tumors. Diagn. Cytopathol. 44, 363–368. https://doi.org/10.1002/dc.23447
  18. Phillips, P.P.J., Dooley, K.E., Gillespie, S.H., Heinrich, N., Stout, J.E., Nahid, P., Diacon, A.H., Aarnoutse, R.E., Kibiki, G.S., Boeree, M.J., Hoelscher, M., 2016a. A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP). BMC Med. 14, 51. https://doi.org/10.1186/s12916-016-0597-3
  19. Phillips, P.P.J., Mendel, C.M., Burger, D.A., Crook, A.M., Nunn, A.J., Dawson, R., Diacon, A.H., Gillespie, S.H., 2016b. Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials. BMC Med. 14, 19. https://doi.org/10.1186/s12916-016-0565-y
  20. Pym, A.S., Diacon, A.H., Tang, S.-J., Conradie, F., Danilovits, M., Chuchottaworn, C., Vasilyeva, I., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., Van Baelen, B., van Heeswijk, R.P.G., Dannemann, B., TMC207-C209 Study Group, 2016. Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. Eur. Respir. J. 47, 564–74. https://doi.org/10.1183/13993003.00724-2015
  21. van Niekerk, G., Davids, L.M., Hattingh, S.M., Engelbrecht, A.-M., 2017. Cancer stem cells: A product of clonal evolution? Int. J. Cancer 140, 993–999. https://doi.org/10.1002/ijc.30448
  22. van Niekerk, G., Hattingh, S.M., Engelbrecht, A.-M., 2016. Enhanced Therapeutic Efficacy in Cancer Patients by Short-term Fasting: The Autophagy Connection. Front. Oncol. 6, 242. https://doi.org/10.3389/fonc.2016.00242
  23. van Vuuren, D., Marais, E., Genade, S., Lochner, A., 2016. The differential effects of FTY720 on functional recovery and infarct size following myocardial ischaemia/reperfusion. Cardiovasc. J. Afr. 27, 375–386. https://doi.org/10.5830/CVJA-2016-039?

2015

Journal Articles

  1. Boeree, M.J., Diacon, A.H., Dawson, R., Narunsky, K., Du Bois, J., Venter, A., Phillips, P.P.J., Gillespie, S.H., McHugh, T.D., Hoelscher, M., Heinrich, N., Rehal, S., Van Soolingen, D., Van Ingen, J., Magis-Escurra, C., Burger, D., Van Balen, G.P., Aarnoutse, R.E., 2015. A dose-ranging trial to optimize the dose of rifampin in the treatment of tuberculosis. Am. J. Respir. Crit. Care Med. 191, 1058–1065. https://doi.org/10.1164/rccm.201407-1264OC
  2. Bowness, R., Boeree, M.J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N.E., Kohlenberg, A., Mtafya, B., Phillips, P.P.J., Rachow, A., Plemper van Balen, G., Gillespie, S.H., 2015. The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. J. Antimicrob. Chemother. 70, 448–455. https://doi.org/10.1093/jac/dku415
  3. Dawson, R., Diacon, A.H., Everitt, D., van Niekerk, C., Donald, P.R., Burger, D.A., Schall, R., Spigelman, M., Conradie, A., Eisenach, K., Venter, A., Ive, P., Page-Shipp, L., Variava, E., Reither, K., Ntinginya, N.E., Pym, A., von Groote-Bidlingmaier, F., Mendel, C.M., 2015. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. Lancet 385, 1738–1747. https://doi.org/10.1016/S0140-6736(14)62002-X
  4. De Wet, D.R., Wright, C.A., Schubert, P.T., Koegelenberg, C.F.N., Louw, M., Diacon, A.H., 2015. Mediastinal granulomatous lymphadenitis in a population at risk for HIV and tuberculosis. Diagn. Cytopathol. 43, 696–700. https://doi.org/10.1002/dc.23280
  5. Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Van Niekerk, C., Everitt, D., Hutchings, J., Burger, D.A., Schall, R., Mendel, C.M., 2015. Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline. Am. J. Respir. Crit. Care Med. 191, 943–953. https://doi.org/10.1164/rccm.201410-1801OC
  6. Donald, P.R., Diacon, A.H., 2015. Para-aminosalicylic acid: the return of an old friend. Lancet Infect. Dis. 15, 1091–1099. https://doi.org/10.1016/S1473-3099(15)00263-7
  7. du Plessis, Stefan S, Agarwal, A., Mohanty, G., van der Linde, M., 2015. Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use? Asian J. Androl. 17, 230–5. https://doi.org/10.4103/1008-682X.135123
  8. du Plessis, Stefan S., Agarwal, A., Syriac, A., 2015. Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility. J. Assist. Reprod. Genet. 32, 1575–1588. https://doi.org/10.1007/s10815-015-0553-8
  9. Espach, Y., Lochner, A., Strijdom, H., Huisamen, B., 2015. ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease. Cardiovasc. Drugs Ther. 29, 51–58. https://doi.org/10.1007/s10557-015-6571-z
  10. George, C, Dietrich, D., Huisamen, B., 2015. The Effect of Chronic Prosopis glandulosa Treatment on Muscle Force Development and Fatigue Tolerance in Soleus Muscle. Br. J. Appl. Sci. Technol. 10, 1–10. https://doi.org/10.9734/BJAST/2015/17032
  11. George, Cindy, Smith, C., Isaacs, A., Huisamen, B., 2015. Chronic Prosopis Glandulosa Treatment Blunts Neutrophil Infiltration and Enhances Muscle Repair after Contusion Injury. Nutrients 7, 815–830. https://doi.org/10.3390/nu7020815
  12. Harlev, A., Agarwal, A., Gunes, S.O., Shetty, A., du Plessis, S.S., 2015. Smoking and Male Infertility: An Evidence-Based Review. World J. Mens. Health 33, 143. https://doi.org/10.5534/wjmh.2015.33.3.143
  13. Heinrich, N., Dawson, R., du Bois, J., Narunsky, K., Horwith, G., Phipps, A.J., Nacy, C.A., Aarnoutse, R.E., Boeree, M.J., Gillespie, S.H., Venter, A., Henne, S., Rachow, A., Phillips, P.P.J., Hoelscher, M., Diacon, A.H., Mekota, A.M., Heinrich, N., Rachow, A., Saathoff, E., Hoelscher, M., Gillespie, S., Colbers, A., van Balen, G.P., Aarnoutse, R., Boeree, M., Bateson, A., McHugh, T., Singh, K., Hunt, R., Zumla, A., Nunn, A., Phillips, P., Rehal, S., Dawson, R., Narunsky, K., Diacon, A., du Bois, J., Venter, A., Friedrich, S., Sanne, I., Mellet, K., Churchyard, G., Charalambous, S., Mwaba, P., Elias, N., Mangu, C., Rojas-Ponce, G., Mtafya, B., Maboko, L., Minja, L.T., Sasamalo, M., Reither, K., Jugheli, L., Sam, N., Kibiki, G., Semvua, H., Mpagama, S., Alabi, A., Adegnika, A.A., Amukoye, E., Okwera, A., 2015. Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients. J. Antimicrob. Chemother. 70, 1558–1566. https://doi.org/10.1093/jac/dku553
  14. Karinja, M.N., Esterhuizen, T.M., Friedrich, S.O., Diacon, A.H., 2015. Sputum volume predicts sputum mycobacterial load during the first 2 weeks of antituberculosis treatment. J. Clin. Microbiol. 53, 1087–91. https://doi.org/10.1128/JCM.02379-14
  15. Kayigire, X.A., Friedrich, S.O., van der Merwe, L., Donald, P.R., Diacon, A.H., 2015. Simultaneous staining of sputum smears for acid-fast and lipid-containing Myobacterium tuberculosis can enhance the clinical evaluation of antituberculosis treatments. Tuberculosis 95, 770–779. https://doi.org/10.1016/J.TUBE.2015.08.001
  16. Koegelenberg, C.F.N., Irusen, E.M., von Groote-Bidlingmaier, F., Bruwer, J.W., Batubara, E.M.A., Diacon, A.H., 2015. The utility of ultrasound-guided thoracentesis and pleural biopsy in undiagnosed pleural exudates. Thorax 70, 995–7. https://doi.org/10.1136/thoraxjnl-2014-206567
  17. Mayorga-Torres, B.J.M., Camargo, M., Agarwal, A., du Plessis, S.S., Cadavid, ?.P., Cardona Maya, W.D., 2015. Influence of ejaculation frequency on seminal parameters. Reprod. Biol. Endocrinol. 13, 47. https://doi.org/10.1186/s12958-015-0045-9
  18. Oyeyipo, I.P., Maartens, P.J., du Plessis, S.S., 2015. Diet-induced obesity alters kinematics of rat spermatozoa. Asian Pacific J. Reprod. 4, 235–239. https://doi.org/10.1016/J.APJR.2015.06.008
  19. Rullas, J., Dhar, N., McKinney, J.D., García-Pérez, A., Lelievre, J., Diacon, A.H., Hugonnet, J.-E., Arthur, M., Angulo-Barturen, I., Barros-Aguirre, D., Ballell, L., 2015. Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection. Antimicrob. Agents Chemother. 59, 4997–9. https://doi.org/10.1128/AAC.01063-15
  20. Slabbert, M., du Plessis, S.S., Huyser, C., 2015. Large volume cryoprotectant-free vitrification: an alternative to conventional cryopreservation for human spermatozoa. Andrologia 47, 594–599. https://doi.org/10.1111/and.12307
  21. Solomons, R.S., Visser, D.H., Friedrich, S.O., Diacon, A.H., Hoek, K.G.P., Marais, B.J., Schoeman, J.F., van Furth, A.M., 2015. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int. J. Tuberc. Lung Dis. 19, 74–80. https://doi.org/10.5588/ijtld.14.0394
  22. Sy, S.K.B., de Kock, L., Diacon, A.H., Werely, C.J., Xia, H., Rosenkranz, B., van der Merwe, L., Donald, P.R., 2015. N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis. Antimicrob. Agents Chemother. 59, 4129–38. https://doi.org/10.1128/AAC.04049-14
  23. Vorster, M.J., Allwood, B.W., Diacon, A.H., Koegelenberg, C.F.N., 2015. Tuberculous pleural effusions: advances and controversies. J. Thorac. Dis. 7, 981–91. https://doi.org/10.3978/j.issn.2072-1439.2015.02.18?

2014

Journal Articles

  1. Agarwal, A., Durairajanayagam, D., du Plessis, S.S., 2014a. Utility of antioxidants during assisted reproductive techniques: an evidence-based review. Reprod. Biol. Endocrinol. 12, 112. https://doi.org/10.1186/1477-7827-12-112
  2. Agarwal, A., Virk, G., Ong, C., du Plessis, S.S., 2014b. Effect of Oxidative Stress on Male Reproduction. World J. Mens. Health 32, 1. https://doi.org/10.5534/wjmh.2014.32.1.1
  3. Bowness, R., Boeree, M.J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N.E., Kohlenberg, A., Mtafya, B., Phillips, P.P.J., Rachow, A., Plemper van Balen, G., Gillespie, S.H., 2015. The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. J. Antimicrob. Chemother. 70, 448–455. https://doi.org/10.1093/jac/dku415
  4. Chellan, N., Joubert, E., Strijdom, H., Roux, C., Louw, J., Muller, C., 2014. Aqueous Extract of Unfermented Honeybush (Cyclopia maculata) Attenuates STZ-induced Diabetes and β-cell Cytotoxicity. Planta Med. 80, 622–629. https://doi.org/10.1055/s-0034-1368457
  5. de Kock, L., Sy, S.K.B., Rosenkranz, B., Diacon, A.H., Prescott, K., Hernandez, K.R., Yu, M., Derendorf, H., Donald, P.R., 2014. Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis. Antimicrob. Agents Chemother. 58, 6242–50. https://doi.org/10.1128/AAC.03073-14
  6. Diacon, A.H., Pym, A., Grobusch, M.P., de los Rios, J.M., Gotuzzo, E., Vasilyeva, I., Leimane, V., Andries, K., Bakare, N., De Marez, T., Haxaire-Theeuwes, M., Lounis, N., Meyvisch, P., De Paepe, E., van Heeswijk, R.P.G., Dannemann, B., 2014a. Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline. N. Engl. J. Med. 371, 723–732. https://doi.org/10.1056/NEJMoa1313865
  7. Diacon, A.H., van der Merwe, L., Demers, A.-M., von Groote-Bidlingmaier, F., Venter, A., Donald, P.R., 2014b. Time to positivity in liquid culture predicts colony forming unit counts of Mycobacterium tuberculosis in sputum specimens. Tuberculosis 94, 148–151. https://doi.org/10.1016/J.TUBE.2013.12.002
  8. Diacon, A.H., van der Merwe, L., Demers, A.-M., Von Groote-Bidlingmaier, F., Venter, A., Donald, P.R., 2014c. Pre-treatment mycobacterial sputum load influences individual on-treatment measurements. Tuberculosis 94, 690–694. https://doi.org/10.1016/J.TUBE.2014.08.015
  9. Dludla, P.V., Muller, C.J.F., Louw, J., Joubert, E., Salie, R., Opoku, A.R., Johnson, R., 2014. The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats. Phytomedicine 21, 595–601. https://doi.org/10.1016/J.PHYMED.2013.10.029
  10. Donald, P.R., Diacon, A.H., 2008. The early bactericidal activity of anti-tuberculosis drugs: a literature review. Tuberculosis 88, S75–S83. https://doi.org/10.1016/S1472-9792(08)70038-6
  11. Flint, M., du Plessis, S.S., Menkveld, R., 2014. Revisiting the assessment of semen viscosity and its relationship to leucocytospermia. Andrologia 46, 837–841. https://doi.org/10.1111/and.12157
  12. Govender, J., Loos, B., Marais, E., Engelbrecht, A.-M., 2014. Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. J. Pineal Res. 57, 367–380. https://doi.org/10.1111/jpi.12176
  13. Kibleur, Y., Brochart, H., Schaaf, H.S., Diacon, A.H., Donald, P.R., 2014. Dose Regimen of Para-Aminosalicylic Acid Gastro-Resistant Formulation (PAS-GR) in Multidrug-Resistant Tuberculosis. Clin. Drug Investig. 34, 269–276. https://doi.org/10.1007/s40261-014-0172-7
  14. Kolwijck, E., Friedrich, S.O., Karinja, M.N., van Ingen, J., Warren, R.M., Diacon, A.H., 2014. Early stationary phase culture supernatant accelerates growth of sputum cultures collected after initiation of anti-tuberculosis treatment. Clin. Microbiol. Infect. 20, O418–O420. https://doi.org/10.1111/1469-0691.12441
  15. Lampiao, F., Huussen, J., Plessis, S.D., 2014. Effects of Nitric Oxide Exposure on Human Sperm Function and Apoptosis Markers. Open Reprod. Sci. J. 6, 17–20. https://doi.org/10.2174/1874255601406010017
  16. Nduhirabandi, F., Huisamen, B., Strijdom, H., Blackhurst, D., Lochner, A., 2014. Short-term melatonin consumption protects the heart of obese rats independent of body weight change and visceral adiposity. J. Pineal Res. 57, 317–332. https://doi.org/10.1111/jpi.12171
  17. Salie, R., Huisamen, B., Lochner, A., 2014. High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury. Cardiovasc. Diabetol. 13, 109. https://doi.org/10.1186/s12933-014-0109-8
  18. Slabbert, M., du Plessis, S.S., Huyser, C., 2015. Large volume cryoprotectant-free vitrification: an alternative to conventional cryopreservation for human spermatozoa. Andrologia 47, 594–599. https://doi.org/10.1111/and.12307
  19. Solomons, R.S., Visser, D.H., Friedrich, S.O., Diacon, A.H., Hoek, K.G.P., Marais, B.J., Schoeman, J.F., van Furth, A.M., 2015. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int. J. Tuberc. Lung Dis. 19, 74–80. https://doi.org/10.5588/ijtld.14.0394
  20. Streicher, E.M., Maharaj, K., York, T., Van Heerden, C., Barnard, M., Diacon, A., Mendel, C.M., Bosman, M.E., Hepple, J.A., Pym, A.S., Warren, R.M., van Helden, P.D., 2014. Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility. J. Clin. Microbiol. 52, 4056–7. https://doi.org/10.1128/JCM.02438-14
  21. Van Rensburg, A., Neethling, G.S., Schubert, P.T., Koegelenberg, C.F.N., Wright, C.A., Bolliger, C.T., Bernasconi, M., Diacon, A.H., 2014. Impact of routine sputum cytology in a population at high risk for bronchial carcinoma. Int. J. Tuberc. Lung Dis. 18, 607–612. https://doi.org/10.5588/ijtld.13.0806
  22. Wallis, R.S., Dawson, R., Friedrich, S.O., Venter, A., Paige, D., Zhu, T., Silvia, A., Gobey, J., Ellery, C., Zhang, Y., Eisenach, K., Miller, P., Diacon, A.H., 2014. Mycobactericidal Activity of Sutezolid (PNU-100480) in Sputum (EBA) and Blood (WBA) of Patients with Pulmonary Tuberculosis. PLoS One 9, e94462. https://doi.org/10.1371/journal.pone.0094462
  23. Webster, I., Smith, A., Lochner, A., Huisamen, B., 2014. Sanguinarine Non- Versus Re-Circulation During Isolated Heart Perfusion - A Jekyll and Hyde Effect? Cardiovasc. Drugs Ther. 28, 489–491. https://doi.org/10.1007/s10557-014-6543-8
  24. Zhu, T., Friedrich, S.O., Diacon, A., Wallis, R.S., 2014. Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis. Antimicrob. Agents Chemother. 58, 3306–11. https://doi.org/10.1128/AAC.01920-13?

2013
Journal Articles
  1. Brundyn, K., Koegelenberg, C.F.N., Diacon, A.H., Louw, M., Schubert, P., Bolliger, C.T., van den Heuvel, M.M., Wright, C.A., 2013. Transbronchial fine needle aspiration biopsy and rapid on-site evaluation in the setting of superior vena cava syndrome. Diagn. Cytopathol. 41, 324–329. https://doi.org/10.1002/dc.21857
  2. Dawson, R., Diacon, A., 2013. PA-824, moxifloxacin and pyrazinamide combination therapy for tuberculosis. Expert Opin. Investig. Drugs 22, 927–932. https://doi.org/10.1517/13543784.2013.801958
  3. Diacon, A.H., Dawson, R., Von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., Conradie, A., Erondu, N., Ginsberg, A.M., Egizi, E., Winter, H., Becker, P., Mendel, C.M., 2013a. Randomized dose-ranging study of the 14-day early bactericidal activity of bedaquiline (TMC207) in patients with sputum microscopy smear-positive pulmonary tuberculosis. Antimicrob. Agents Chemother. 57, 2199–203. https://doi.org/10.1128/AAC.02243-12
  4. Diacon, A.H., Donald, P.R., Mendel, C.M., 2013b. Early bactericidal activity of new drug regimens for tuberculosis - Authors' reply. Lancet (London, England) 381, 112–3. https://doi.org/10.1016/S0140-6736(13)60042-2
  5. Dooley, K.E., Nuermberger, E.L., Diacon, A.H., 2013. Pipeline of drugs for related diseases: tuberculosis. Curr. Opin. HIV AIDS 8, 579–85. https://doi.org/10.1097/COH.0000000000000009
  6. Du Plessis, S., Gokul, S., Agarwal, A., 2013. Semen hyperviscosity: causes, consequences, and cures. Front. Biosci. 5, 224–231.
  7. Flepisi, T.B., Lochner, A., Huisamen, B., 2013. The Consequences of Long-Term Glycogen Synthase Kinase-3 Inhibition on Normal and Insulin Resistant Rat Hearts. Cardiovasc. Drugs Ther. 27, 381–392. https://doi.org/10.1007/s10557-013-6467-8
  8. Flint, M., Du Plessis, S.S., 2013. Trichomonas vaginalis in Sub-Saharan Africa?: occurrence and diagnostic approaches for the male partner. Med. Technol. SA 27, 26–28.
  9. Friedrich, S.O., Rachow, A., Saathoff, E., Singh, K., Mangu, C.D., Dawson, R., Phillips, P.P., Venter, A., Bateson, A., Boehme, C.C., Heinrich, N., Hunt, R.D., Boeree, M.J., Zumla, A., McHugh, T.D., Gillespie, S.H., Diacon, A.H., Hoelscher, M., 2013. Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment. Lancet Respir. Med. 1, 462–470. https://doi.org/10.1016/S2213-2600(13)70119-X
  10. Hamada, A., Sharma, R., du Plessis, S.S., Willard, B., Yadav, S.P., Sabanegh, E., Agarwal, A., 2013. Two-dimensional differential in-gel electrophoresis–based proteomics of male gametes in relation to oxidative stress. Fertil. Steril. 99, 1216-1226.e2. https://doi.org/10.1016/J.FERTNSTERT.2012.11.046
  11. Huisamen, B., George, C., Dietrich, D., Genade, S., 2013. Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes. Cardiovasc. J. Afr. 24, 10–6. https://doi.org/10.5830/CVJA-2012-069
  12. Kayigire, X.A., Friedrich, S.O., Venter, A., Dawson, R., Gillespie, S.H., Boeree, M.J., Heinrich, N., Hoelscher, M., Diacon, A.H., Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics, 2013. Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity. J. Clin. Microbiol. 51, 1894–8. https://doi.org/10.1128/JCM.03290-12
  13. Koegelenberg, C.F.N., Diacon, A.H., 2013. Image-guided pleural biopsy. Curr. Opin. Pulm. Med. 19, 368–373. https://doi.org/10.1097/MCP.0b013e32835f4c23
  14. Kolwijck, E., Mitchell, M., Venter, A., Friedrich, S.O., Dawson, R., Diacon, A.H., 2013. Short-term storage does not affect the quantitative yield of Mycobacterium tuberculosis in sputum in early-bactericidal-activity studies. J. Clin. Microbiol. 51, 1094–8. https://doi.org/10.1128/JCM.02751-12
  15. Lampiao, F., Du Plessis, S., 2013. New developments of the effect of melatonin on reproduction. World J. Obstet. Gynecol. 2, 15–22.
  16. Liwa, A.C., Schaaf, H.S., Rosenkranz, B., Seifart, H.I., Diacon, A.H., Donald, P.R., 2013. Para-Aminosalicylic Acid Plasma Concentrations in Children in Comparison with Adults after Receiving a Granular Slow-Release Preparation. J. Trop. Pediatr. 59, 90–94. https://doi.org/10.1093/tropej/fms053
  17. Lochner, A., Huisamen, B., Nduhirabandi, F., 2013. Cardioprotective effect of melatonin against ischaemia/reperfusion damage. Front. Biosci. 5, 305–315.
  18. Mor, Z., Leventhal, A., Diacon, A.H., Finger, R., Schoch, O.D., 2013. Tuberculosis screening in immigrants from high-prevalence countries: Interview first or chest radiograph first? A pro/con debate. Respirology 18, 432–438. https://doi.org/10.1111/resp.12054
  19. Sharma, R., Agarwal, A., Mohanty, G., Du Plessis, S.S., Gopalan, B., Willard, B., Yadav, S.P., Sabanegh, E., 2013a. Proteomic analysis of seminal fluid from men exhibiting oxidative stress. Reprod. Biol. Endocrinol. 11, 85. https://doi.org/10.1186/1477-7827-11-85
  20. Sharma, R., Agarwal, A., Mohanty, G., Hamada, A.J., Gopalan, B., Willard, B., Yadav, S., du Plessis, S., 2013b. Proteomic analysis of human spermatozoa proteins with oxidative stress. Reprod. Biol. Endocrinol. 11, 48. https://doi.org/10.1186/1477-7827-11-48
  21. von Groote-Bidlingmaier, F., Koegelenberg, C.F., Bolliger, C.T., Chung, P.K., Rautenbach, C., Wasserman, E., Bernasconi, M., Friedrich, S.O., Diacon, A.H., 2013. The yield of different pleural fluid volumes for Mycobacterium tuberculosis culture. Thorax 68, 290–1. https://doi.org/10.1136/thoraxjnl-2012-202338?

2012
Journal Articles
  1. Aboua, Y.G., Brooks, N., Mahfouz, R.Z., Agarwal, A., du Plessis, S.S., 2012. A red palm oil diet can reduce the effects of oxidative stress on rat spermatozoa. Andrologia 44, 32–40. https://doi.org/10.1111/j.1439-0272.2010.01133.x
  2. Bernasconi, M., Koegelenberg, C.F.N., von Groote-Bidlingmaier, F., Maree, D., Barnard, B.J., Diacon, A.H., Bolliger, C.T., 2012. Speed of Ascent During Stair Climbing Identifies Operable Lung Resection Candidates. Respiration 84, 117–122. https://doi.org/10.1159/000337258
  3. Carr, I.M., Koegelenberg, C.F.N., von Groote-Bidlingmaier, F., Mowlana, A., Silos, K., Haverman, T., Diacon, A.H., Bolliger, C.T., 2012. Blood Loss during Flexible Bronchoscopy: A Prospective Observational Study. Respiration 84, 312–318. https://doi.org/10.1159/000339507
  4. Chellan, N., Muller, C.J.F., de Beer, D., Joubert, E., Page, B.J., Louw, J., 2012. An in vitro assessment of the effect of Athrixia phylicoides DC. aqueous extract on glucose metabolism. Phytomedicine 19, 730–736. https://doi.org/10.1016/J.PHYMED.2012.03.006
  5. Diacon, A., von, G.-B., Donald, P., 2012. From Magic Mountain to Table Mountain. Swiss Med. Wkly. 142. https://doi.org/10.4414/smw.2012.13665
  6. Diacon, Andreas H, Dawson, R., du Bois, J., Narunsky, K., Venter, A., Donald, P.R., van Niekerk, C., Erondu, N., Ginsberg, A.M., Becker, P., Spigelman, M.K., 2012a. Phase II dose-ranging trial of the early bactericidal activity of PA-824. Antimicrob. Agents Chemother. 56, 3027–31. https://doi.org/10.1128/AAC.06125-11
  7. Diacon, Andreas H, Dawson, R., von Groote-Bidlingmaier, F., Symons, G., Venter, A., Donald, P.R., van Niekerk, C., Everitt, D., Winter, H., Becker, P., Mendel, C.M., Spigelman, M.K., 2012b. 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial. Lancet 380, 986–993. https://doi.org/10.1016/S0140-6736(12)61080-0
  8. Diacon, A H, Donald, P.R., Pym, A., Grobusch, M., Patientia, R.F., Mahanyele, R., Bantubani, N., Narasimooloo, R., De Marez, T., van Heeswijk, R., Lounis, N., Meyvisch, P., Andries, K., McNeeley, D.F., 2012. Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance. Antimicrob. Agents Chemother. 56, 3271–6. https://doi.org/10.1128/AAC.06126-11
  9. Khullar, K., Agarwal, A., du Plessis, S., 2012. A hormonal, physical, and proteomic view of obesity-induced effects on male infertility and possible lifestyle modifications. Asian Pacific J. Reprod. 1, 161–168. https://doi.org/10.1016/S2305-0500(13)60071-8
  10. Louw, M., Brundyn, K., Schubert, P.T., Wright, C.A., Bolliger, C.T., Diacon, A.H., 2012. Comparison of the quality of smears in transbronchial fine-needle aspirates using two staining methods for rapid on-site evaluation. Diagn. Cytopathol. 40, 777–781. https://doi.org/10.1002/dc.21628
  11. Maarman, G., Marais, E., Lochner, A., du Toit, E.F., 2012. Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity. Cardiovasc. Drugs Ther. 26, 205–216. https://doi.org/10.1007/s10557-012-6377-1
  12. Mudau, M., Genis, A., Lochner, A., Strijdom, H., 2012. Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc. J. Afr. 23, 222–231. https://doi.org/10.5830/CVJA-2011-068
  13. Nduhirabandi, F., du Toit, E.F., Lochner,  a., 2012. Melatonin and the metabolic syndrome: A tool for effective therapy in obesity-associated abnormalities? Acta Physiol. 205, 209–223. https://doi.org/10.1111/j.1748-1716.2012.02410.x
  14. Rengan, A.K., Agarwal, A., van der Linde, M., du Plessis, S.S., 2012. An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet. Reprod. Biol. Endocrinol. 10, 92. https://doi.org/10.1186/1477-7827-10-92
  15. Sadie-Van Gijsen, H., Smith, W., du Toit, E.F., Michie, J., Hough, F.S., Ferris, W.F., 2012. Depot-specific and hypercaloric diet-induced effects on the osteoblast and adipocyte differentiation potential of adipose-derived stromal cells. Mol. Cell. Endocrinol. 348, 55–66. https://doi.org/10.1016/J.MCE.2011.07.030
  16. Salie, R., Moolman, J.A., Lochner, A., 2012. The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation. Basic Res. Cardiol. 107, 281. https://doi.org/10.1007/s00395-012-0281-5
  17. Strijdom, H., 2012. Endothelial dysfunction: are we ready to heed the vasculature's early-warning signal? Cardiovasc. J. Afr. 23, 184–5.
  18. van Jaarsveld, F.P., Hattingh, S., 2016. Rapid Induction of Ageing Character in Brandy Products. Ageing and General Overview. South African J. Enol. Vitic. 33. https://doi.org/10.21548/33-2-1122
  19. Walters, E., Gie, R.P., Hesseling, A.C., Friedrich, S.O., Diacon, A.H., Gie, R.P., 2012. Rapid Diagnosis of Pediatric Intrathoracic Tuberculosis From Stool Samples Using the Xpert MTB/RIF Assay. Pediatr. Infect. Dis. J. 31, 1316. https://doi.org/10.1097/INF.0b013e318266c21c
  20. Webster, I., Du Toit, E.F., Huisamen, B., Lochner, A., 2012. The effect of creatine supplementation on myocardial function, mitochondrial respiration and susceptibility to ischaemia/reperfusion injury in sedentary and exercised rats. Acta Physiol. 206, 6–19. https://doi.org/10.1111/j.1748-1716.2012.02463.x?

2011

Journal Articles
?
  1. Awoniyi, D., Aboua, Y., Marnewick, J., Plesis, S. du, Brooks, N., 2011. Protective effects of rooibos (Aspalathus linearis), green tea (Camellia sinensis) and commercial supplements on testicular tissue of oxidative stress-induced rats. AFRICAN J. Biotechnol. 10, 17317–17322. https://doi.org/10.5897/AJB11.2210
  2. Bernasconi, M., Bolliger, C.T., Irusen, E., Diacon, A.H., 2011. A Left Hemithorax Mystery. Respiration 82, 557–559. https://doi.org/10.1159/000330594
  3. Clark, C., Smith, W., Lochner, A., Toit, E.F.D., 2011. The effects of gender and obesity on myocardial tolerance to ischemia. Physiol. Res. 60, 291–301. https://doi.org/10.33549/physiolres.931999
  4. Diacon, A. H., Dawson, R., Hanekom, M., Narunsky, K., Venter, A., Hittel, N., Geiter, L.J., Wells, C.D., Paccaly, A.J., Donald, P.R., 2011. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int. J. Tuberc. Lung Dis. 15, 949–954. https://doi.org/10.5588/ijtld.10.0616
  5. Diacon, Andreas H., Maritz, J.S., Donald, P.R., 2011. Chapter 21: Early Bactericidal Activity of Antituberculosis Agents. Karger Publishers, pp. 213–219. https://doi.org/10.1159/000324633
  6. du Plessis, S., Agarwal, A., 2011. Taking the stress out of ART induced oxidative stress. ACE Newsl. Focus 2, 11–14.
  7. DU PLESSIS, S.S., KASHOU, A., VAAMONDE, D., AGARWA, A., 2011. Is There a Link between Exercise and Male Factor Infertility? Open Reprod. Sci. J. 3, 105–113.
  8. du Plessis, S.S., Kashou, A.H., Benjamin, D.J., Yadav, S.P., Agarwal, A., 2011. Proteomics: a subcellular look at spermatozoa. Reprod. Biol. Endocrinol. 9, 36. https://doi.org/10.1186/1477-7827-9-36
  9. Essop, M.F., Chan, W.A., Hattingh, S., 2011. Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes. Cardiovasc. J. Afr. 22, 175–8. https://doi.org/10.5830/CVJA-2010-058
  10. Friedrich, S.O., Venter, A., Kayigire, X.A., Dawson, R., Donald, P.R., Diacon, A.H., 2011a. Suitability of Xpert MTB/RIF and genotype MTBDRplus for patient selection for a tuberculosis clinical trial. J. Clin. Microbiol. 49, 2827–31. https://doi.org/10.1128/JCM.00138-11
  11. Friedrich, S.O., von Groote-Bidlingmaier, F., Diacon, A.H., 2011b. Xpert MTB/RIF assay for diagnosis of pleural tuberculosis. J. Clin. Microbiol. 49, 4341–2. https://doi.org/10.1128/JCM.05454-11
  12. George, C., Lochner, A., Huisamen, B., 2011. The efficacy of Prosopis glandulosa as antidiabetic treatment in rat models of diabetes and insulin resistance. J. Ethnopharmacol. 137, 298–304. https://doi.org/10.1016/J.JEP.2011.05.023
  13. Huisamen, Barbara, Genis, A., Marais, E., Lochner, A., 2011. Pre-treatment with a DPP-4 Inhibitor is Infarct Sparing in Hearts from Obese, Pre-diabetic Rats. Cardiovasc. Drugs Ther. 25, 13–20. https://doi.org/10.1007/s10557-010-6271-7
  14. Huisamen, B., Pêrel, S.J.C., Friedrich, S.O., Salie, R., Strijdom, H., Lochner, A., 2011. ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance. Mol. Cell. Biochem. 349, 21–31. https://doi.org/10.1007/s11010-010-0656-6
  15. Kashou, A.H., Benjamin, D.J., Agarwal, A., du Plessis, S.S., 2011. The Advent of Sperm Proteomics has Arrived. Open Reprod. Sci. J. 3, 92–97. https://doi.org/10.2174/1874255601103010092
  16. KOEGELENBERG, C.F.N., DIACON, A.H., 2011. Pleural controversy: Closed needle pleural biopsy or thoracoscopy-Which first? Respirology 16, 738–746. https://doi.org/10.1111/j.1440-1843.2011.01973.x
  17. Koegelenberg, C.F.N., Diacon, A.H., Irusen, E.M., von Groote-Bidlingmaier, F., Mowlana, A., Wright, C.A., Louw, M., Schubert, P.T., Bolliger, C.T., 2011. The Diagnostic Yield and Safety of Ultrasound-Assisted Transthoracic Biopsy of Mediastinal Masses. Respiration 81, 134–141. https://doi.org/10.1159/000322005
  18. Lampiao, F., Slabbert, M., Plessis, S., 2011. The in vitro anti-fertility effects of Acacia nilotica on human spermatozoa function. Spat. DD - Peer Rev. J. Complement. Med. Drug Discov. 1, 59. https://doi.org/10.5455/spatula.20110321061343
  19. Lochner, A., 2011. Signalling during an ischaemic preconditioning protocol: new role players? Cardiovasc. Res. 90, 5–6. https://doi.org/10.1093/cvr/cvr045
  20. Loos, B., Genade, S., Ellis, B., Lochner, A., Engelbrecht, A.-M., 2011a. At the core of survival: Autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury. Exp. Cell Res. 317, 1437–1453. https://doi.org/10.1016/J.YEXCR.2011.03.011
  21. Loos, B., Lochner, A., Engelbrecht, A.-M., 2011b. Autophagy in heart disease: A strong hypothesis for an untouched metabolic reserve. Med. Hypotheses 77, 52–57. https://doi.org/10.1016/J.MEHY.2011.03.021
  22. McCarthy, J., Lochner, A., Opie, L.H., Sack, M.N., Essop, M.F., 2011. PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition. J. Cell. Physiol. 226, 2457–2468. https://doi.org/10.1002/jcp.22592
  23. Nduhirabandi, F., du Toit, F., Blackhurst, D., Marais, D., Lochner, A., Du Toit, E.F., Blackhurst, D., Marais, D., Lochner, A., 2011. Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity. J. Pineal Res. 50, 171–182. https://doi.org/10.1111/j.1600-079X.2010.00826.x
  24. Salie, R., Moolman, J.A., Lochner, A., 2011. The Role of β-adrenergic Receptors in the Cardioprotective Effects of Beta-Preconditioning (βPC). Cardiovasc. Drugs Ther. 25, 31–46. https://doi.org/10.1007/s10557-010-6275-3
  25. Sishi, B., Loos, B., Ellis, B., Smith, W., Toit, E.F. du, Engelbrecht, A., 2011. Diet‐induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp. Physiol. 96, 179–193. https://doi.org/10.1113/EXPPHYSIOL.2010.054189@10.1002
  26. Webster, I., Huisamen, B., Du Toit, E.F., 2011. Creatine and Exercise – Strong Evidence for Stronger Heart Muscle? J. Exerc. Physiol. 14, 85–108. https://doi.org/10.1519/JSC.0b013e3181874564
  27. Webster, I., Toit, E.F. Du, Huisamen, B., 2010. The effects of long term swim training on physiological stress levels in the rat. Med. Technol. South Africa 24, 37–40.?

2010 and Earlier

  1. Aboua Y.G., Du Plessis SS, Brooks N, Y.G., 2007. In vitro Red Palm Oil (RPO) administration to human spermatozoa: Finding a suitable solvent. Med Technol. SA 21, 7–9.
  2. Aboua, Y.G., du Plessis, S.S., Reichgelt, P., Brooks, N., 2009. The in vitro effects of superoxide, some commercially available antioxidants and red palm oil on sperm motility. Asian J. Androl. 11, 695–702. https://doi.org/10.1038/aja.2009.55
  3. Agarwal, A., Du Plessis, S.S., Cabler, S., Sabanegh E., 2010. Fertility fears - fate of the fat. Eur. Urol. Rev.  5, 60–64.
  4. Arvola, L., Bertelsen, E., Lochner, A., Ytrehus, K., 2006. Sustained anti-β-adrenergic effect of melatonin in guinea pig heart papillary muscle. Scand. Cardiovasc. J. 40, 37–42. https://doi.org/10.1080/14017430500339347
  5. Bester, E.P., Mouton, R., Malan, J.F., Lochner, A., 1993. The effect of lithium on the heart. Cardiovasc. J. Afr. 4, 210–214.
  6. Botha, M., Kruger, T., Agarwal, A., du Plessis, S., 2009. Fertility sparing surgery for female cancer patients complementing cryotechniques. Arch. Med. Sci. Spec. Issues 2009, 183–183.
  7. Brunner, F., Mouton, R., Lochner, A., Opie, L.H. 1995. Defective Stretch-Induced Release of Atrial Natriuretic Peptide from Aging Hypertensive Rat Heart. J. Cardiovasc. Pharmacol. 25, 168–176. https://doi.org/10.1097/00005344-199501000-00026
  8. Cabler, S., Agarwal, A., Flint, M., du Plessis, S.S., 2010. Obesity: modern man's fertility nemesis. Asian J. Androl. 12, 480–9. https://doi.org/10.1038/aja.2010.38
  9. Carstens, N., van der Merwe, L., Revera, M., Heradien, M., Goosen, A., Brink, P.A., Moolman-Smook, J.C., 2011. Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure. J. Renin. Angiotensin. Aldosterone. Syst. 12, 274–80. https://doi.org/10.1177/1470320310390725
  10. Chegou, N.N., Walzl, G., Bolliger, C.T., Diacon, A.H., van den Heuvel, M.M., 2008. Evaluation of Adapted Whole-Blood Interferon-γ Release Assays for the Diagnosis of Pleural Tuberculosis. Respiration 76, 131–138. https://doi.org/10.1159/000128575
  11. Cilhers, G.D., Lochner, A., 1993. Radiation-induced damage of the Wistar rat heart: biochemistry and function. Radiother. Oncol. 27, 216–222. https://doi.org/10.1016/0167-8140(93)90077-L
  12. Cilliers, F.J., Warren, R.M., Hauman, J.H., Wiid, I.J., van Helden, P.D., 1997. Oligonucleotide (GTG)5 as an epidemiological tool in the study of nontuberculous mycobacteria. J. Clin. Microbiol. 35, 1545–9.
  13. Cilliers, G.D., Lochner, A., 1993. Biochemical and functional effects of radiation-induced damage of the Wistar rat heart. S. Afr. J. Sci. 89, 537–541.
  14. Coetzee, A., Moolman, J., 1997. Regional pressure-length relations during acute myocardial ischaemia and prolonged post-ischaemic dysfunction (stunning). Cardiovasc. J. South Africa.
  15. Coetzee, A., Skein, W., Genade, S., Lochner, A. 1993. Enflurane and Isoflurane Reduce Reperfusion Dysfunction in the Isolated Rat Heart. Anesth. Analg. 76, 602–608. https://doi.org/10.1213/00000539-199303000-00027
  16. COETZEE, I.H., HARPER, I.S., GENADE, S., LOCHNER, A., 1994. Effect of H2O2 on the ultrastructure, sarcolemmal permeability and mechanical performance of the isolated rat heart. S. Afr. J. Sci. 90, 17–21.
  17. Coetzee, I.H., Lochner, A., IH, C., A., L., 1993. Free radical effects on myocardial membrane microviscosity. Cardioscience 4, 205–15.
  18. Coetzee, J.F., le Roux, P.J., Genade, S., Lochner, A., 2000. Reduction of Postischemic Contractile Dysfunction of the Isolated Rat Heart by Sevoflurane: Comparison with Halothane. Anesth. Analg. 90, 1089–1097. https://doi.org/10.1097/00000539-200005000-00016
  19. Daniels, W. M. U., Pietersen, C.Y., Carstens, M.E., Stein, D.J., 2004a. Maternal Separation in Rats Leads to Anxiety-Like Behavior and a Blunted ACTH Response and Altered Neurotransmitter Levels in Response to a Subsequent Stressor. Metab. Brain Dis. 19, 3–14. https://doi.org/10.1023/B:MEBR.0000027412.19664.b3
  20. Daniels, W. M. U., Richter, L., Stein, D.J., 2004b. The Effects of Repeated Intra-Amygdala CRF Injections on Rat Behavior and HPA Axis Function After Stress. Metab. Brain Dis. 19, 15–23. https://doi.org/10.1023/B:MEBR.0000027413.42946.61
  21. Daniels, W.M.U., Fairbairn, L.R., van Tilburg, G., McEvoy, C.R.E., Zigmond, M.J., Russell, V.A., Stein, D.J., 2009. Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 17 glucocorticoid receptor promoter region. Metab. Brain Dis. 24, 615–627. https://doi.org/10.1007/s11011-009-9163-4
  22. Daniels, W.M.U., Hendricks, J., Salie, R., Taljaard, J.J.F., 2001. The Role of the MAP-Kinase Superfamily in β-Amyloid Toxicity. Metab. Brain Dis. 16, 175–185. https://doi.org/10.1023/A:1012541011123
  23. Daniels, W.M.U., Rensburg, S.J., Zyl, J.M., Taljaard, J.J.F., 1998. Melatonin prevents??-amyloid-induced lipid peroxidation. J. Pineal Res. 24, 78–82. https://doi.org/10.1111/j.1600-079X.1998.tb00370.x
  24. Daniels, W.M.U., van Rensburg, S.J., van Zyl, J.M., van der Walt, B.J., Taljaard, J.J.F., WM, D., SJ,  van R., JM,  van Z., BJ,  van der W., JJ., T., 1996. Free radical scavenging effects of melatonin and serotonin. Neuroreport 7, 1593–1596. https://doi.org/10.1097/00001756-199607080-00012
  25. Daniels, Willie M. U., Hendricks, J., Salie, R., van Rensburg, S.J., 2004. A Mechanism for Zinc Toxicity in Neuroblastoma Cells. Metab. Brain Dis. 19, 79–88. https://doi.org/10.1023/B:MEBR.0000027419.79032.bd
  26. Davids, M.R., Muller, C.J., Rossouw, D.J., Doubell, A.F., 1998. The role of the endothelium in the reduction of restenosis following balloon angioplasty (568). Cardiovasc. J. Afr. 5, 1–1.
  27. de Glanville, N., Lochner, A. & Coetzee, A., 1998. Effects of adrenaline, administered early or later after ischaemia, and reperfusion on the isolated rat heart. Cardiovasc. J. Afr. 9, 35–39.
  28. Diacon, A.H., 2010. Iodopovidone as a pleurodesis agent: Setting standards for clinical pleural research. Respirology 15, 4–5. https://doi.org/10.1111/j.1440-1843.2009.01654.x
  29. Diacon, A.H., Koegelenberg, C.F.N., Schubert, P., Brundyn, K., Louw, M., Wright, C.A., Bolliger, C.T., 2010. Rapid on-site evaluation of transbronchial aspirates: randomised comparison of two methods. Eur. Respir. J. 35, 1216–20. https://doi.org/10.1183/09031936.00050809
  30. Diacon, A.H., Maritz, J.S., Venter, A., Helden, P.D., Andries, K., McNeeley, D.F., Donald, P.R., 2010. Time to detection of the growth of Mycobacterium tuberculosis in MGIT 960 for determining the early bactericidal activity of antituberculosis agents. Eur. J. Clin. Microbiol. Infect. Dis. 29, 1561–1565. https://doi.org/10.1007/s10096-010-1043-7
  31. Diacon, A.H., Pym, A., Grobusch, M., Patientia, R., Rustomjee, R., Page-Shipp, L., Pistorius, C., Krause, R., Bogoshi, M., Churchyard, G., Venter, A., Allen, J., Palomino, J.C., De Marez, T., van Heeswijk, R.P.G., Lounis, N., Meyvisch, P., Verbeeck, J., Parys, W., de Beule, K., Andries, K., Neeley, D.F.M., 2009. The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. N. Engl. J. Med. 360, 2397–2405. https://doi.org/10.1056/NEJMoa0808427
  32. Diacon, Andreas H, Dawson, R., Hanekom, M., Narunsky, K., Maritz, S.J., Venter, A., Donald, P.R., van Niekerk, C., Whitney, K., Rouse, D.J., Laurenzi, M.W., Ginsberg, A.M., Spigelman, M.K., 2010. Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients. Antimicrob. Agents Chemother. 54, 3402–7. https://doi.org/10.1128/AAC.01354-09
  33. Djoba Siawaya, J.F., Chegou, N.N., Heuvel, M.M. van den, Diacon, A.H., Beyers, N., Helden, P. van, Walzl, G., 2009. Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis. Cytokine 47, 132–136. https://doi.org/10.1016/J.CYTO.2009.05.016
  34. Donald, P.R., Diacon, A.H., 2008. The early bactericidal activity of anti-tuberculosis drugs: a literature review. Tuberculosis 88, S75–S83. https://doi.org/10.1016/S1472-9792(08)70038-6
  35. Donthi, R. V., Huisamen, B., Lochner, A., 2000. Effect of Vanadate and Insulin on Glucose Transport in Isolated Adult Rat Cardiomyocytes. Cardiovasc. Drugs Ther. 14, 463–470. https://doi.org/10.1023/A:1007876703644
  36. Du Plessis, S. S., McAllister, D.A., Luu, A., Savia, J., Agarwal, A., Lampiao, F., 2010. Effects of H2O2 exposure on human sperm motility parameters, reactive oxygen species levels and nitric oxide levels. Andrologia 42, 206–210. https://doi.org/10.1111/j.1439-0272.2009.00980.x
  37. Du Plessis, S., 2006. Reactive oxygen species measurement in human spermatozoa by flow cytometry using the fluorescent probe, 2',7'-dichlorofluorescein-diacetate (DCFH-DA). Med. Technol. SA 20, 9–10.
  38. du Plessis, S.., van Niekerk, F.., Coetzer, W.., 1999a. The effect of dietary molybdenum and sulphate on the oestrus cycle and ovulation in ewes after manipulation with exogenous progesterone alone or in combination with FSH and LH. Small Rumin. Res. 33, 63–69. https://doi.org/10.1016/S0921-4488(99)00002-4
  39. du Plessis, S.., Van Niekerk, F.., Coetzer, W.., 1999b. The effect of dietary molybdenum and sulphate on sexual activity and plasma progesterone concentrations of ewes. Small Rumin. Res. 33, 71–76. https://doi.org/10.1016/S0921-4488(99)00004-8
  40. Du Plessis, S.S., Aboua, Y.G., Brooks, N., Awoniyi, D.O., 2009. Red palm oil?: a natural good samaritan for sperm apoptosis? Med. Technol. SA 1, 8–10.
  41. du Plessis, S.S., de Jongh, P.S., Franken, D.R., 2004. Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function. Fertil. Steril. 81, 1026–1033. https://doi.org/10.1016/J.FERTNSTERT.2003.09.054
  42. Du Plessis, S.S., Franken, D.R., Baldi, E., Luconi, M., 2004. Phosphatidylinositol 3-kinase inhibition enhances human sperm motility and sperm-zona pellucida binding. Int. J. Androl. 27, 19–26. https://doi.org/10.1111/j.1365-2605.2004.00440.x
  43. du Plessis, S.S., Hagenaar, K., Lampiao, F., 2010. The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROS. Andrologia 42, 112–116. https://doi.org/10.1111/j.1439-0272.2009.00964.x
  44. du Plessis, S.S., Makker, K., Desai, N.R., Agarwal, A., 2008. Impact of oxidative stress on IVF. Expert Rev. Obstet. Gynecol. 3, 539–554. https://doi.org/10.1586/17474108.3.4.539
  45. du Plessis, S.S., Page, C., Franken, D.R., 2001. The zona pellucida-induced acrosome reaction of human spermatozoa involves extracellular signal-regulated kinase activation. Andrologia 33, 337–342. https://doi.org/10.1046/j.1439-0272.2001.00449.x
  46. Du Plessis, S.S., Page, C., Franken, D.R., 2002. Extracellular signal-regulated kinase activation involved in human sperm-zona pellucida binding. Andrologia 34, 55–59. https://doi.org/10.1046/j.0303-4569.2001.00475.x
  47. Du Plessis, Stefan S., Cabler, S., McAlister, D.A., Sabanegh, E., Agarwal, A., 2010. The effect of obesity on sperm disorders and male infertility. Nat. Rev. Urol. 7, 153–161. https://doi.org/10.1038/nrurol.2010.6
  48. du Toit, E F, Genis, A., Opie, L.H., Pollesello, P., Lochner, A., 2008. A role for the RISK pathway and K ATP channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart. Br. J. Pharmacol. 154, 41–50. https://doi.org/10.1038/bjp.2008.52
  49. du Toit, E., Hofmann, D., McCarthy, J., Pineda, C., 2001. Effect of levosimendan on myocardial contractility, coronary and peripheral blood flow, and arrhythmias during coronary artery ligation and reperfusion in the in vivo pig model. Heart 86, 81–7. https://doi.org/10.1136/heart.86.1.81
  50. du Toit, E.F., Genade, S., Carlini, S., Moolman, J.A., Brunner, F., Lochner, A., 2007. Efficacy of ischaemic preconditioning in the eNOS overexpressed working mouse heart model. Eur. J. Pharmacol. 556, 115–120. https://doi.org/10.1016/J.EJPHAR.2006.11.004
  51. Du Toit, E.F., Meiring, J., Opie, L.H., 2001. Relation of cyclic nucleotide ratios to ischemic and reperfusion injury in nitric oxide-donor treated rat hearts. J. Cardiovasc. Pharmacol. 38, 529–538. https://doi.org/10.1097/00005344-200110000-00005
  52. du Toit, E.F., Rossouw, E., Salie, R., Opie, L.H., Lochner, A., 2005. Effect of Sildenafil on Reperfusion Function, Infarct Size, and Cyclic Nucleotide Levels in the Isolated Rat Heart Model. Cardiovasc. Drugs Ther. 19, 23–31. https://doi.org/10.1007/s10557-005-6894-2
  53. du Toit, Eugene F., Smith, W., Muller, C., Strijdom, H., Stouthammer, B., Woodiwiss, A.J., Norton, G.R., Lochner, A., 2008. Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity. Am. J. Physiol. Circ. Physiol. 294, H2336–H2343. https://doi.org/10.1152/ajpheart.00481.2007
  54. Edoute, Y., Giris, J., Ben-Haim, S.A., Lochner, A., Weizman, A., Hayam, G., Katz, Y., Gavish, M., 1993. Ro 5-4864 and PK 11195, but Not Diazepam, Depress Cardiac Function in an Isolated Working Rat Heart Model. Pharmacology 46, 224–230. https://doi.org/10.1159/000139049
  55. Engelbrecht, A.-M., Engelbrecht, P., Genade, S., Niesler, C., Page, C., Smuts, M., Lochner, A., 2005. Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway. J. Mol. Cell. Cardiol. 39, 940–954. https://doi.org/10.1016/J.YJMCC.2005.08.004
  56. Engelbrecht, A.-M., Esterhuyse, J., du Toit, E.F., Lochner, A., van Rooyen, J., 2006a. p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart? J. Nutr. Biochem. 17, 265–271. https://doi.org/10.1016/J.JNUTBIO.2005.05.001
  57. Engelbrecht, A.-M., Esterhuyse, J., du Toit, E.F., Lochner, A., van Rooyen, J., 2006b. p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart? J. Nutr. Biochem. 17, 265–271. https://doi.org/10.1016/J.JNUTBIO.2005.05.001
  58. Engelbrecht, A.M., Louw, L., Cloete, F., 1998. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part II, free fatty acid profiles. Prostaglandins, Leukot. Essent. Fat. Acids 59, 253–257. https://doi.org/10.1016/S0952-3278(98)90138-7
  59. Engelbrecht, A.-M., Niesler, C., Page, C., Lochner, A., 2004. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res. Cardiol. 99, 338–350. https://doi.org/10.1007/s00395-004-0478-3
  60. Engelbrecht, A.-M., Odendaal, L., Du Toit, E.F., Kupai, K., Czont, T., Ferdinandy, P., van Rooyen, J., 2009. The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-Kinase signaling pathway. Lipids Health Dis. 8, 18. https://doi.org/10.1186/1476-511X-8-18
  61. Essop, M.F., Anna Chan, W.Y., Valle, A., García-Palmer, F.J., Du Toit, E.F., 2009. Impaired contractile function and mitochondrial respiratory capacity in response to oxygen deprivation in a rat model of pre-diabetes. Acta Physiol. 197, 289–296. https://doi.org/10.1111/j.1748-1716.2009.02024.x
  62. Esterhuyse, A.J., du Toit, E.F., Benadè, A.J.S., van Rooyen, J., 2005. Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet. Prostaglandins, Leukot. Essent. Fat. Acids 72, 153–161. https://doi.org/10.1016/J.PLEFA.2004.10.014
  63. Esterhuyse, J.S., van Rooyen, J., Strijdom, H., Bester, D., du Toit, E.F., 2006. Proposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the rat. Prostaglandins, Leukot. Essent. Fat. Acids 75, 375–384. https://doi.org/10.1016/J.PLEFA.2006.07.001
  64. Fan, W.-J., Genade, S., Genis, A., Huisamen, B., Lochner, A., 2009. Dexamethasone-induced cardioprotection: A role for the phosphatase MKP-1? Life Sci. 84, 838–846. https://doi.org/10.1016/J.LFS.2009.03.014
  65. Fan, W.J., Vuuren, D., Genade, S., Lochner, A., 2010. Kinases and phosphatases in ischaemic preconditioning: a re-evaluation. Basic Res. Cardiol. 105, 495–511. https://doi.org/10.1007/s00395-010-0086-3
  66. Faure, J., Stein, D.J., Daniels, W., 2009. Maternal separation fails to render animals more susceptible to methamphetamine-induced conditioned place preference. Metab. Brain Dis. 24, 541–559. https://doi.org/10.1007/s11011-009-9158-1
  67. Faure, J., Uys, J.D.K., Marais, L., Stein, D.J., Daniels, W.M.U., 2007. Early maternal separation alters the response to traumatization: resulting in increased levels of hippocampal neurotrophic factors. Metab. Brain Dis. 22, 183–195. https://doi.org/10.1007/s11011-007-9048-3
  68. Faure, J., Uys, J.D.K., Marais, L., Stein, D.J., Daniels, W.M.U., 2006. Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model. Metab. Brain Dis. 21, 172–179. https://doi.org/10.1007/s11011-006-9013-6
  69. Faure, J.J., Hattingh, S.M., Stein, D.J., Daniels, W.M., 2009. Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment. Metab. Brain Dis. 24, 685–700. https://doi.org/10.1007/s11011-009-9167-0
  70. Fourie, P.R., Coetzee, A.R., 1993. Effect of compliance on a time-domain estimate of the characteristic impedance of the pulmonary artery during acute pulmonary hypertension. Med. Biol. Eng. Comput. 31, 468–474. https://doi.org/10.1007/BF02441981
  71. Fourie, P.R., Coetzee, A.R., Bolliger, C.T., 1992. Pulmonary artery compliance: its role in right ventricular-arterial coupling. Cardiovasc. Res. 26, 839–844. https://doi.org/10.1093/cvr/26.9.839
  72. Fuglesteg, B.N., Suleman, N., Tiron, C., Kanhema, T., Lacerda, L., Andreasen, T. V., Sack, M.N., Jonassen, A.K., Mj?s, O.D., Opie, L.H., Lecour, S., 2008. Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion. Basic Res. Cardiol. 103, 444–453. https://doi.org/10.1007/s00395-008-0728-x
  73. Genade, B., Schoonwinkel, A., Wessels, J., 1996. Overview and comparison of methologies for 3D human motion analysis. Elektron 13, 30-32.
  74. Genade, S., Genis, A., Ytrehus, K., Huisamen, B., Lochner, A., 2008. Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions. J. Pineal Res. 45, 449–458. https://doi.org/10.1111/j.1600-079X.2008.00615.x
  75. Genade, S., Moolman, J.A., Lochner, A., 2001. Opioid receptor stimulation acts as mediator of protection in ischaemic preconditioning. Cardiovasc. J. South. Africa 18, 8–16.
  76. Georgescu, E.S., Goldberg, J.M., du Plessis, S.S., Agarwal, A., 2008. Present and Future Fertility Preservation Strategies for Female Cancer Patients. Obstet. Gynecol. Surv. 63, 725–732. https://doi.org/10.1097/OGX.0b013e318186aaea
  77. Gross, A.M., Diacon, A.H., Van Den Heuvel, M.M., Van Rensburg, J., Harris, D., Bolliger, C.T., 2009. Management of life-threatening haemoptysis in an area of high tuberculosis incidence. Int. J. Tuberc. Lung Dis. 13, 875–880.
  78. Hampton, P.C., Schach, S.R., Koeslag, J.H. 1993. Has Tay-Sachs disease become common? S. Afr. Med. J. 83, 877–8.
  79. Hattingh, P., Coetzee, A., Harper, I., Genade, S., Lochner, A., 1993. Effects of beta-blockers and Ca2+ -antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest. Cardiovasc. Drugs Ther. 7, 851–861. https://doi.org/10.1007/BF00877715
  80. Hattingh, P.W., Lochner, A., Tromp, E., Coetzee, A., 1997. Alpha-adrenergic receptor stimulation improves myocardial inotropy in the presence of chronic adrenergic antagonists and calcium channel blockers in the isolated rat heart after cardioplegic arrest. Cardiovasc. J. Afr. 87, C277–C284.
  81. Hofmeyr, L., Moolman, J., Brice, E., Weich, H., 2009. An Unusual Presentation of an Anomalous Left Coronary Artery Arising from the Pulmonary Artery (ALCAPA) in an Adult: Anterior Papillary Muscle Rupture Causing Severe Mitral Regurgitation. Echocardiography 26, 474–477. https://doi.org/10.1111/j.1540-8175.2008.00815.x
  82. Hugo, C., Seier, J., Mdhluli, C., Daniels, W., Harvey, B.H., Du Toit, D., Wolfe-Coote, S., Nel, D., Stein, D.J., 2003. Fluoxetine decreases stereotypic behavior in primates. Prog. Neuro-Psychopharmacology Biol. Psychiatry 27, 639–643. https://doi.org/10.1016/S0278-5846(03)00073-3
  83. Huisamen, B., 2003. PKB in diabetic myocardiopathy. Mol. Cell. Biochem. 249, 31–38.
  84. Huisamen, B., Donthi, R. V., Lochner, A., 2001a. Insulin in Combination with Vanadate Stimulates Glucose Transport in Isolated Cardiomyocytes from Obese Zucker Rats. Cardiovasc. Drugs Ther. 15, 445–452. https://doi.org/10.1023/A:1013358011019
  85. Huisamen, B., Ellis, E., van Dyk, M., Lochner, A., 1996. Characterization of inositolpolyphosphate binding to myocardial membranes. Mol. Cell. Biochem. 162, 1–9. https://doi.org/10.1007/BF00250989
  86. Huisamen, B., Genade, S., Lochner, A., 2008. Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia. Cardiovasc. J. Afr. 19, 77–83.
  87. Huisamen, B., Lochner, A., 1996. Inositolpolyphosphates and their binding proteins?alpha-a short review. Mol. Cell. Biochem. 157, 229–232. https://doi.org/10.1007/BF00227903
  88. Huisamen, B., Lochner, A., 2005. Exercise modulates myocardial protein kinase B/Akt in Zucker obese rats. Heart 91, 227–8. https://doi.org/10.1136/hrt.2003.027094
  89. Huisamen, B., Marais, E., Genade, S., Lochner, A., 2001b. Serial changes in the myocardial β-adrenergic signalling system in two models of non-insulin dependent diabetes mellitus. Mol. Cell. Biochem. 219, 73–82. https://doi.org/10.1023/A:1011014909231
  90. Huisamen, B., Mouton, R., Opie, L.H., Lochner, A., 1994a. Effects of ischaemia, reperfusion and α1 receptor stimulation on the inositoltrisphosphate receptor population in rat heart atria and ventricles. Mol. Cell. Biochem. 140, 23–30. https://doi.org/10.1007/BF00928362
  91. Huisamen, B., Mouton, R., Opie, L.H., Lochner, A., 1994b. Demonstration of a Specific [3H]INS(1,4,5)P3 Binding Site in Rat Heart Sarcoplasmic Reticulum. J. Mol. Cell. Cardiol. 26, 341–349. https://doi.org/10.1006/JMCC.1994.1043
  92. Huisamen, B., Upton, J., Lochner, A., 2004. A Role for the α 1 -Adrenergic Signalling Pathway in the Response of Papillary Muscles from Type 2 Diabetic Hearts to Anoxia-Reoxygenation. Cardiovasc. Drugs Ther. 18, 247–255. https://doi.org/10.1023/B:CARD.0000041244.50971.ae
  93. Huisamen, B., van Zyl, M., Keyser, A., Lochner, A., 2001c. The effects of insulin and β-adrenergic stimulation on glucose transport, glut 4 and PKB activation in the myocardium of lean and obese non-insulin dependent diabetes mellitus rats. Mol. Cell. Biochem. 223, 15–25. https://doi.org/10.1023/A:1017528402205
  94. Koegelenberg, C. F. N., Irusen, E.M., Cooper, R., Diacon, A.H., Taljaard, J.J., Mowlana, A., von Groote-Bidlingmaier, F., Bolliger, C.T., 2010. High mortality from respiratory failure secondary to swine-origin influenza A (H1N1) in South Africa. QJM 103, 319–325. https://doi.org/10.1093/qjmed/hcq022
  95. Koegelenberg, C., Diacon, A., 2008. Pleural biopsy for patients with suspected malignant effusions. South African Respir. J. 14, 82–83.
  96. Koegelenberg, C., Diacon, A., 2010a. Ultrasound-assisted pleural biopsies. Int. Pleural Newsl. 2, 8–9.
  97. Koegelenberg, C., Diacon, A., 2010b. Ultrasound-assisted pleural biopsies. South African Respir. J.  16, 88.
  98. Koegelenberg, C.F.N., Bolliger, C.T., Plekker, D., Wright, C.A., Brundyn, K., Louw, M., Schubert, P., van den Heuvel, M.M., Diacon, A.H., 2009. Diagnostic yield and safety of ultrasound-assisted biopsies in superior vena cava syndrome. Eur. Respir. J. 33, 1389–95. https://doi.org/10.1183/09031936.00128108
  99. Koegelenberg, C.F.N., Diacon, A.H., Irani, S., Bolliger, C.T., 2008a. Stair Climbing in the Functional Assessment of Lung Resection Candidates. Respiration 75, 374–379. https://doi.org/10.1159/000116873
  100. Koegelenberg, C.F.N., Diaconi, A.H., Bolligeri, C.T., 2008b. Parapneumonic Pleural Effusion and Empyema. Respiration 75, 241–250. https://doi.org/10.1159/000117172
  101. Koegelenberg, Coenraad Frederik N, Bolliger, C.T., Theron, J., Walzl, G., Wright, C.A., Louw, M., Diacon, A.H., 2010. Direct comparison of the diagnostic yield of ultrasound-assisted Abrams and Tru-Cut needle biopsies for pleural tuberculosis. Thorax 65, 857–862. https://doi.org/10.1136/THX.2009.125146
  102. Koen, C., Koeslag, J., 1995. On the Stability of Subatmospheric Intrapleural and Intracranial Pressures. Physiology 10, 176–178. https://doi.org/10.1152/physiologyonline.1995.10.4.176
  103. Koeslag, J., Saunders, P., 2004. The Role of Chromogranins and Other Statins in Homeostasis: An Explanation of the Precise Regulation of Glucose and Ionised Calcium in the Blood; An Overview. Curr. Med. Chem. Endocr. Metab. Agents 4, 235–249. https://doi.org/10.2174/1568013043357716
  104. Koeslag, J.D., Koeslag, P.D., 1993. The mechanics of bi-articular muscles. S. Afr. J. Sci. 89, 73–76.
  105. Koeslag, J.H., 1993. What is normal? South African Med. J. 83, 47–50.
  106. Koeslag, J.H., 1994. Koinophilia Replaces Random Mating in Populations Subject to Mutations with Randomly Varying Fitnesses. J. Theor. Biol. 171, 341–345. https://doi.org/10.1006/JTBI.1994.1236
  107. Koeslag, J.H., 1995. On the Engine of Speciation. J. Theor. Biol. 177, 401–409. https://doi.org/10.1006/JTBI.1995.0256
  108. Koeslag, J.H., 1997. Sex, The Prisoner's Dilemma Game, and the Evolutionary Inevitability of Cooperation. J. Theor. Biol. 189, 53–61. https://doi.org/10.1006/JTBI.1997.0496
  109. Koeslag, J.H., Koeslag, P.D., 1993. Evolutionarily Stable Meiotic Sex. J. Hered. 84, 396–399. https://doi.org/10.1093/oxfordjournals.jhered.a111360
  110. Koeslag, J.H., Koeslag, P.D., 1994. Koinophilia. J. Theor. Biol. 167, 55–65. https://doi.org/10.1006/JTBI.1994.1049
  111. Koeslag, J.H., Saunders, P.T., Terblanche, E., 2003. A Reappraisal of the Blood Glucose Homeostat which Comprehensively Explains the Type 2 Diabetes Mellitus-Syndrome X Complex. J. Physiol. 549, 333–346. https://doi.org/10.1113/jphysiol.2002.037895
  112. Koeslag, J.H., Saunders, P.T., Wessels, J.A., 1997. Glucose homeostasis with infinite gain: further lessons from the Daisyworld parable? J. Endocrinol. 154, 187–192. https://doi.org/10.1677/joe.0.1540187
  113. Koeslag, J.H., Saunders, P.T., Wessels, J.A., 1999. The chromogranins and the counter-regulatory hormones: do they make homeostatic sense? J. Physiol. 517, 643. https://doi.org/10.1111/J.1469-7793.1999.0643S.X
  114. Koeslag, J.H., Terblanche, E., 2003. Evolution of cooperation: cooperation defeats defection in the cornfield model. J. Theor. Biol. 224, 399–410. https://doi.org/10.1016/S0022-5193(03)00188-7
  115. Koeslag, P.D., Koeslag, J.H., 1994. Koinophilia Stabilizes Bi-gender Sexual Reproduction Against Asex in an Unchanging Environment. J. Theor. Biol. 166, 251–260. https://doi.org/10.1006/JTBI.1994.1023
  116. Kothari, S., Thompson, A., Agarwal, A., du Plessis, S.S., 2010. Free radicals: Their beneficial and detrimental effects on sperm function. Indian J. Exp. Biol. IJEB. 48, 425–435.
  117. Kruger, M.J., Engelbrecht, A.-M., Esterhuyse, J., du Toit, E.F., van Rooyen, J., 2007. Dietary red palm oil reduces ischaemia–reperfusion injury in rats fed a hypercholesterolaemic diet. Br. J. Nutr. 97, 653–660. https://doi.org/10.1017/S0007114507658991
  118. Lackner, J.E., Agarwal, A., Mahfouz, R., du Plessis, S.S., Schatzl, G., 2010. The association between leukocytes and sperm quality is concentration dependent. Reprod. Biol. Endocrinol. 8, 12. https://doi.org/10.1186/1477-7827-8-12
  119. Lambert, E. V, Wooding, G., Lambert, M.I., Koeslag, J.H., Noakes, T.D., 1994. Enhanced adipose tissue lipoprotein lipase activity in detrained rats: independent of changes in food intake. J. Appl. Physiol. 77, 2564–71. https://doi.org/10.1152/jappl.1994.77.6.2564
  120. Lampiano, F., Strijdom, H., du Plessis, S., 2010. Effects of Sperm Processing Techniques Involving Centrifugation on Nitric Oxide, Reactive Oxygen Species Generation and Sperm Function. Open Androl. J. 2, 1–5.
  121. Lampiao, F., Agarwal, A., du Plessis, S.S., 2009. The role of insulin and leptin in male reproduction. Arch Med Sci 5, S48–S54.
  122. Lampiao, F., du Plessis, S.S., 2006. Comparing the Multi-ZSC one-step standardized swim-up method to the double-wash swim-up method with regard to the effects of sperm separation on morphology, head morphometry, and acrosome reaction inducibility. Fertil. Steril. 86, 739–741. https://doi.org/10.1016/J.FERTNSTERT.2006.02.084
  123. Lampiao, F., du Plessis, S.S., 2008a. Insulin and leptin enhance human sperm motility, acrosome reaction and nitric oxide production. Asian J. Androl. 10, 799–807. https://doi.org/10.1111/j.1745-7262.2008.00421.x
  124. Lampiao, F., du Plessis, S.S., 2008b. TNF-α and IL-6 affect human sperm function by elevating nitric oxide production. Reprod. Biomed. Online 17, 628–631. https://doi.org/10.1016/S1472-6483(10)60309-4
  125. Lampiao, F., du Plessis, S.S., 2009. Effects of tumour necrosis factor alpha and interleukin-6 on progesterone and calcium ionophore-induced acrosome reaction. Int. J. Androl. 32, 274–277. https://doi.org/10.1111/j.1365-2605.2008.00922.x
  126. Lampiao, F., du Plessis, S.S., 2010. Insulin Stimulates Glut8 Expression in Human Spermatozoa. J. Biosci. Technol. 1, 90–93.
  127. Lampiao, F., Krom, D., Plessis, S.S. du, 2008. The in vitro effects of Mondia whitei on human sperm motility parameters. Phyther. Res. 22, 1272–1273. https://doi.org/10.1002/ptr.2469
  128. Lampiao, F., Strijdom, H., du Plessis, S.S., 2006. Direct nitric oxide measurement in human spermatozoa: flow cytometric analysis using the fluorescent probe, diaminofluorescein. Int. J. Androl. 29, 564–567. https://doi.org/10.1111/j.1365-2605.2006.00695.x
  129. Lochner, A., 2008. Sarcolemmal permeability changes during ischaemia and reperfusion: release of survival factors. Cardiovasc. Res. 79, 545–546. https://doi.org/10.1093/cvr/cvn186
  130. Lochner, A., Genade, S., 1998. Ischemic preconditioning of the isolated perfused working guinea pig heart. Cardiovasc. Drugs Ther. 12, 495–497. https://doi.org/10.1023/A:1007766403077
  131. Lochner, A., Genade, S., Davids, A., Ytrehus, K., Moolman, J.A., 2006. Short- and long-term effects of melatonin on myocardial post-ischemic recovery. J. Pineal Res. 40, 56–63. https://doi.org/10.1111/j.1600-079X.2005.00280.x
  132. Lochner, A., Genade, S., Hattingh, S., Marais, E., Huisamen, B., Moolman, J.A., 2003a. Comparison Between Ischaemic and Anisomycin-Induced Preconditioning: Role of p38 MAPK. Cardiovasc. Drugs Ther. 17, 217–230. https://doi.org/10.1023/A:1026116022552
  133. Lochner, A., Genade, S., Moolman, J.A., 2003b. Ischemic preconditioning: Infarct size is a more reliable endpoint than functional recovery. Basic Res. Cardiol. 98, 337–346. https://doi.org/10.1007/s00395-003-0427-6
  134. Lochner, A., Genade, S., Tromp, E., Opie, L., Moolman, J., Thomas, S., Podzuweit, T., 1998a. Role of cyclic nucleotide phosphodiesterases in ischemic preconditioning. Mol. Cell. Biochem. 186, 169–175. https://doi.org/10.1023/A:1006800205787
  135. Lochner, A., Genade, S., Tromp, E., Theron, S., Trollip, G., 1998b. Postcardioplegic Myocardial Recovery: Effects of Halothane, Nifedipine, HOE 694, and Quinacrine. Cardiovasc. Drugs Ther. 12, 267–277. https://doi.org/10.1023/A:1007765732582
  136. Lochner, A., Genade, S., Tromp, E., Theron, S., Trollip, G., 1998c. Postcardioplegic Myocardial Recovery: Effects of Halothane, Nifedipine, HOE 694, and Quinacrine. Cardiovasc. Drugs Ther. 12, 267–277. https://doi.org/10.1023/A:1007765732582
  137. Lochner, A., Harper, I.S., Rudwaan, S., Genade, S., Coetzee, A.R., 1994. Halothane Protects the Isolated Rat Myocardium Against Excessive Total Intracellular Calcium and Structural Damage During Ischemia and Reperfusion. Anesth. Analg. 79, 226–233. https://doi.org/10.1213/00000539-199408000-00004
  138. Lochner, A., Huisamen, B., 2010. GSK-3 protein and the heart?: friend or foe? SA Hear. 7, 48–57.
  139. Lochner, A., Koeslag, J.H., Du Toit, E.F., Huisamen, B., Moolman, J.A., Van Rooyen, J., 2004. Cellular injury in ischaemia: editorial comment. Cardiovasc. J. South Africa 15, 2005–2006.
  140. Lochner, A., Marais, E., Genade, S., Moolman, J.A., 2000. Nitric oxide: a trigger for classic preconditioning? Am. J. Physiol. Circ. Physiol. 279, H2752–H2765. https://doi.org/10.1152/ajpheart.2000.279.6.H2752
  141. LOCHNER, A., MARAIS, E., TOIT, E. DU, MOOLMAN, J., 2002. Nitric Oxide Triggers Classic Ischemic Preconditioning. Ann. N. Y. Acad. Sci. 962, 402–414. https://doi.org/10.1111/j.1749-6632.2002.tb04084.x
  142. Lochner, A., Moolman, J.A., 2006. The Many Faces of H89: A Review. Cardiovasc. Drug Rev. 24, 261–274. https://doi.org/10.1111/j.1527-3466.2006.00261.x
  143. Lochner, A., Pentz, A., Williams, K., Tromp, E., Harper, I.S., 1996. Substrate effects on sarcolemmal permeability in the normoxic and hypoxic perfused rat heart. Basic Res. Cardiol. 91, 64–78. https://doi.org/10.1007/bf00788867
  144. Lochner, A., Tromp, E., Mouton, R., 1996. Signal transduction in myocardial ischaemia and reperfusion, in: Biochemical Mechanisms in Heart Function. Springer US, Boston, MA, pp. 129–136. https://doi.org/10.1007/978-1-4613-1279-6_18
  145. Lochner, Amanda, Marais, E., Genade, S., Huisamen, B., Strijdom, H., Moolman, J.A., 2003. Ischaemic and Pharmacological Preconditioning Is Associated with Attenuation of p38 MAPK Activation During Sustained Ischaemia and Reperfusion. Springer, Boston, MA, pp. 249–273. https://doi.org/10.1007/978-1-4615-0355-2_18
  146. Lochner, C., Kinnear, C.J., Hemmings, S.M.J., Seller, C., Niehaus, D.J.H., Knowles, J.A., Daniels, W., Moolman-Smook, J.C., Seedat, S., Stein, D, J., 2005. Hoarding in obsessive-compulsive disorder: Clinical and genetic correlates. J. Clin. Psychiatry  66, 1155–1160.
  147. Lochner, J.D., Schneider, D.J., JD, L., DJ., S., 1994. The relationship between tuberculosis, vitamin D, potassium and AIDS. A message for South Africa? S. Afr. Med. J. 84, 79–82.
  148. Louw, L., Engelbrecht, A.M., Cloete, F., 1998a. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part I, total fatty acid profiles. Prostaglandins, Leukot. Essent. Fat. Acids 59, 247–251. https://doi.org/10.1016/S0952-3278(98)90137-5
  149. Louw, L., Engelbrecht, A.M., Cloete, F., 1998b. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part III, saturated and unsaturated fatty acid profiles. Prostaglandins, Leukot. Essent. Fat. Acids 59, 259–264. https://doi.org/10.1016/S0952-3278(98)90139-9
  150. Lubbe, W.W., Bolliger, C.T., Barnard, B.J., Diacon, A.H., 2008. Cardiac arrest following pneumonectomy. Respiration 76, 225–227. https://doi.org/10.1159/000112792
  151. Mahfouz, R.Z., du Plessis, S.S., Aziz, N., Sharma, R., Sabanegh, E., Agarwal, A., 2010. Sperm viability, apoptosis, and intracellular reactive oxygen species levels in human spermatozoa before and after induction of oxidative stress. Fertil. Steril. 93, 814–821. https://doi.org/10.1016/J.FERTNSTERT.2008.10.068
  152. Majane, O.H.I., Vengethasamy, L., du Toit, E.F., Makaula, S., Woodiwiss, A.J., Norton, G.R., 2009. Dietary-induced obesity hastens the progression from concentric cardiac hypertrophy to pump dysfunction in spontaneously hypertensive rats. Hypertens. (Dallas, Tex.  1979) 54, 1376–83. https://doi.org/10.1161/HYPERTENSIONAHA.108.127514
  153. Makaula, S., Lochner, A., Genade, S., Sack, M.N., Awan, M.M., Opie, L.H., 2005. H-89, a Non-Specific Inhibitor of Protein Kinase A, Promotes Post-Ischemic Cardiac Contractile Recovery and Reduces Infarct Size. J. Cardiovasc. Pharmacol. 45, 341–347. https://doi.org/10.1097/01.fjc.0000156825.80951.14
  154. Marais, E., Genade, S., Huisamen, B., Strijdom, J.G., Moolman, J.A., Lochner, A., 2001. Activation of p38 MAPK Induced by a Multi-cycle Ischaemic Preconditioning Protocol is Associated with Attenuated p38 MAPK Activity During Sustained Ischaemia and Reperfusion. J. Mol. Cell. Cardiol. 33, 769–778. https://doi.org/10.1006/JMCC.2001.1347
  155. Marais, E., Genade, S., Lochner, A., 2008. CREB Activation and Ischaemic Preconditioning. Cardiovasc. Drugs Ther. 22, 3–17. https://doi.org/10.1007/s10557-007-6078-3
  156. Marais, E., Genade, S., Salie, R., Huisamen, B., Maritz, S., Moolman, J.A., Lochner, A., 2005a. The temporal relationship between p38 MAPK and HSP27 activation in ischaemic and pharmacological preconditioning. Basic Res. Cardiol. 100, 35–47. https://doi.org/10.1007/s00395-004-0495-7
  157. Marais, E., Genade, S., Salie, R., Huisamen, B., Maritz, S., Moolman, J.A., Lochner, A., 2005b. The temporal relationship between p38 MAPK and HSP27 activation in ischaemic and pharmacological preconditioning. Basic Res. Cardiol. 100, 35–47. https://doi.org/10.1007/s00395-004-0495-7
  158. Marais, Erna, Genade, S., Strijdom, H., Moolman, J.A., Lochner, A., 2001. p38 MAPK Activation Triggers Pharmacologically-induced β -adrenergic Preconditioning, but Not Ischaemic Preconditioning. J. Mol. Cell. Cardiol. 33, 2157–2177. https://doi.org/10.1006/JMCC.2001.1478
  159. Marais, L., Daniels, W., Brand, L., Viljoen, F., Hugo, C., Stein, D.J., 2006. Psychopharmacology of maternal separation anxiety in vervet monkeys. Metab. Brain Dis. 21, 191–200. https://doi.org/10.1007/s11011-006-9011-8
  160. Marais, L., Hattingh, S.M., Stein, D.J., Daniels, W.M.U., 2009a. A proteomic analysis of the ventral hippocampus of rats subjected to maternal separation and escitalopram treatment. Metab. Brain Dis. 24, 569–586. https://doi.org/10.1007/s11011-009-9156-3
  161. Marais, L., Stein, D.J., Daniels, W.M.U., 2009b. Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats. Metab. Brain Dis. 24, 587–597. https://doi.org/10.1007/s11011-009-9157-2
  162. Marais, L., van Rensburg, S.J., van Zyl, J.M., Stein, D.J., Daniels, W.M.U., 2008. Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neurosci. Res. 61, 106–112. https://doi.org/10.1016/J.NEURES.2008.01.011
  163. Maree, L., du Plessis, S.S., Menkveld, R., van der Horst, G., 2010. Morphometric dimensions of the human sperm head depend on the staining method used. Hum. Reprod. 25, 1369–1382. https://doi.org/10.1093/humrep/deq075
  164. McCarthy, J., Lochner, A., Genade, S., Ping, P., Essop, M.F., Sack, M.N., Opie, L.H., 2008. Hypoxic hearts overexpressing activated PKC epsilon (aPKCe) have decreased cardiac function on exposure to fatty acid perfusate. J. Mol. Cell. Cardiol. 44, 761. https://doi.org/10.1016/j.yjmcc.2008.02.120
  165. Melchiorri, D., Ortiz, G., Reiter, R., Sewerynek, E., Daniels, W.M., Pablos, M.., Nisticò, G., 1998. Melatonin reduces paraquat-induced genotoxicity in mice. Toxicol. Lett. 95, 103–108. https://doi.org/10.1016/S0378-4274(98)00025-3
  166. Miller, D.M., Wessels, J.A., 1997. A simple method for the continuous noninvasive estimate of cardiac output using the Maxima breathing system. A pilot study. Anaesth. Intensive Care 25, 23–8. https://doi.org/10.1177/0310057X9702500104
  167. Moolman, J. A., Genade, S., Tromp, E., Lochner, A., 1996. A comparison between ischemic preconditioning and anti-adrenergic interventions: cAMP, energy metabolism and functional recovery. Basic Res. Cardiol. 91, 219–233. https://doi.org/10.1007/BF00788908
  168. MOOLMAN, J., 2006. Unravelling the cardioprotective mechanism of action of estrogens. Cardiovasc. Res. 69, 777–780. https://doi.org/10.1016/j.cardiores.2006.01.001
  169. Moolman, J.A., 2002. Thyroid hormone and the heart: review article. Cardiovasc. J. South Africa 13, 159-163.
  170. Moolman, J.A., Genade, S., Tromp, E., Opie, L.H., Lochner, A., 1997. Ischaemic preconditioning does not protect hypertrophied myocardium against ischaemia. Cardiovasc. J. Afr. 8, 151–156.
  171. Moolman, J.A., Genade, S., Winterbach, R., Harper, I.S., Williams, K., Lochner, A., 1995. Preconditioning with a single short episode of global ischemia in the isolated working rat heart: Effect on structure, mechanical function, and energy metabolism for various durations of sustained global ischemia. Cardiovasc. Drugs Ther. 9, 103–115. https://doi.org/10.1007/BF00877750
  172. Moolman, J.A., Genade, S., Winterbach, R., Lochner, A., 1994. Preconditioning with hypoxia versus global ischemia in the isolated rat heart: effect on function and metabolism. Cardioscience 5, 73–80.
  173. Moolman, J.A., Hartley, S., Van Wyk, J., Marais, E., Lochner, A., 2006. Inhibition of Myocardial Apoptosis by Ischaemic and Beta-Adrenergic Preconditioning is Dependent on p38 MAPK. Cardiovasc. Drugs Ther. 20, 13–25. https://doi.org/10.1007/s10557-006-6257-7
  174. Moolman, J.A., Lochner, A., 1994. Ischaemic preconditioning - laboratory phenomenon or relevant to clinical practice? Cardiovasc. J. Afr. 5, 127–134.
  175. MOOLMAN, J.A., REITH, S., UHL, K., BAILEY, S., GAUTEL, M., JESCHKE, B., FISCHER, C., OCHS, J., McKENNA, W.J., KLUES, H., VOSBERG, H.-P., 2000. A newly created splice donor site in exon 25 of the MyBP-C gene is responsible for inherited hypertrophic cardiomyopathy with incomplete disease penetrance. Circulation 101, 1396–1402.
  176. Moolman, Johannes Albertus, Genade, S., Tromp, E., Lochner, A., 1996. No evidence for mediation of ischemic preconditioning by alpha1-adrenergic signal transduction pathway or protein kinase C in the isolated rat heart. Cardiovasc. Drugs Ther. 10, 125–136. https://doi.org/10.1007/BF00823590
  177. Pan African Society of Cardiology., S., Ytrehus, K., Lochner, A., 2006. Melatonin prevents cardioprotection inducedby a multi-cycle ischaemic preconditioning protocol in the isolated perfused rat heart: cardiovascular topics. Cardiovasc. J. South Africa 17, 239–244.
  178. Pienaar, I.S., Schallert, T., Hattingh, S., Daniels, W.M.U., 2009. Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration. J. Neural Transm. 116, 791–806. https://doi.org/10.1007/s00702-009-0247-4
  179. Plekker, D., Ellis, T., Irusen, E.M., Bolliger, C.T., Diacon, A.H., 2008. Clinical and Radiological Grading of Superior Vena Cava Obstruction. Respiration 76, 69–75. https://doi.org/10.1159/000108921
  180. Rensburg, S.J. van, Daniels, W.M.U., Potocnik, F.C.V., Zyl, J.M. van, Taljaard, J.J.F., Emsley, R.A., 1997. A new model for the pathophysiology of Alzheimer's disease: Aluminium toxicity is exacerbated by hydrogen peroxide and attenuated by an amyloid protein fragment and melatonin. South African Med. J. 87, 1111–1115.
  181. Rustomjee, R., Diacon, A.H., Allen, J., Venter, A., Reddy, C., Patientia, R.F., Mthiyane, T.C.P., De Marez, T., van Heeswijk, R., Kerstens, R., Koul, A., De Beule, K., Donald, P.R., McNeeley, D.F., 2008. Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis. Antimicrob. Agents Chemother. 52, 2831–5. https://doi.org/10.1128/AAC.01204-07
  182. Salie, R., Harper, I., Cillie, C., Genade, S., Huisamen, B., Moolman, J., Lochner, A., 2001. Melatonin Protects Against Ischaemic-reperfusion Myocardial Damage. J. Mol. Cell. Cardiol. 33, 343–357. https://doi.org/10.1006/JMCC.2000.1306
  183. Saunders, P.T., Koeslag, J.H., Wessels, J.A., 1998. Integral Rein Control in Physiology. J. Theor. Biol. 194, 163–173. https://doi.org/10.1006/JTBI.1998.0746
  184. SAUNDERS, P.T., KOESLAG, J.H., WESSELS, J.A., 2000. Integral Rein Control in Physiology II: a General Model. J. Theor. Biol. 206, 211–220. https://doi.org/10.1006/JTBI.2000.2118
  185. Smit, E., Conradie, M., Wessels, J., Witbooi, I., Otto, R., 2003. Measurement of the magnitude of force applied by students when learning a mobilisation technique. South African J. Physiother. 59, 3–8. https://doi.org/10.4102/sajp.v59i4.206
  186. Sorokin, A., Weich, H., Doubell, A., Moolman, J.A., 2006. Bilateral ostial coronary stenosis and rheumatic aortic valve stenosis. Acute Card. Care 8, 113–115. https://doi.org/10.1080/14628840600717641
  187. Stein, D.J., Collins, M., Daniels, W., Noakes, T.D., Zigmond, M., 2007. Mind and Muscle: The Cognitive-Affective Neuroscience of Exercise. CNS Spectr. 12, 19–22. https://doi.org/10.1017/S1092852900020484
  188. Stein, D.J., Daniels, W., Emsley, R., Harvey, B., Blackburn, J., Carey, P., Ellis, G., Illing, N., Flisher, A., Moolman-Smook, H., Mwaba, K., Ramesar, R., Russell, V., Seedat, S., Tredoux, C., Vaughan, C.L., Vythilingum, B., Warwick, J., 2006. A brain-behaviour initiative for South Africa: the time is right. Metab. Brain Dis. 21, 266–271. https://doi.org/10.1007/s11011-006-9024-3
  189. Stein, D.J., Harvey, B.H., Uys, J., Daniels, W., 2005. Suffer the Children: The Psychobiology of Early Adversity. CNS Spectr. 10, 612–615. https://doi.org/10.1017/S1092852900019568
  190. Strijdom, H., Chamane, N., Lochner, A., 2009a. Nitric oxide in the cardiovascular system: a simple molecule with complex actions. Cardiovasc. J. Afr. 20, 303–10.
  191. Strijdom, H., Friedrich, S.O., Hattingh, S., Chamane, N., Lochner, A., 2009b. Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes and the role of the PI3-K/PKB pathway. Mol. Cell. Biochem. 321, 23–35. https://doi.org/10.1007/s11010-008-9906-2
  192. Strijdom, H., Genade, S., Lochner, A., 2004a. Nitric Oxide Synthase (NOS) Does Not Contribute to Simulated Ischaemic Preconditioning in an Isolated Rat Cardiomyocyte Model. Cardiovasc. Drugs Ther. 18, 99–112. https://doi.org/10.1023/B:CARD.0000029027.50796.84
  193. Strijdom, H., Jacobs, S., Hattingh, S., Page, C., Lochner, A., 2006. Nitric oxide production is higher in rat cardiac microvessel endothelial cells than ventricular cardiomyocytes in baseline and hypoxic conditions: a comparative study. FASEB J. 20, 314–316. https://doi.org/10.1096/fj.05-4225fje
  194. Strijdom, H., Lochner, A., 2009. Cardiac endothelium?: more than just a barrier?: cardiac endothelium. SA Hear. 6, 174–185.
  195. Strijdom, H., Muller, C., Lochner, A., 2004b. Direct intracellular nitric oxide detection in isolated adult cardiomyocytes: flow cytometric analysis using the fluorescent probe, diaminofluorescein. J. Mol. Cell. Cardiol. 37, 897–902. https://doi.org/10.1016/J.YJMCC.2004.05.018
  196. STRIJDOM, J.G., MARAIS, B.J., KOESLAG, J.H., 1992. Ascorbic acid causes spuriously low blood glucose measurements. South African Med. J. 81, 379–389.
  197. Terblanche, E., Cloete, W.A., du Plessis, P.A.L., Sadie, J.N., Strauss, A., Unger, M., 2003. The metabolic transition speed between backward walking and running. Eur. J. Appl. Physiol. 90, 520–525. https://doi.org/10.1007/s00421-003-0890-7
  198. Terblanche, E., Page, C., Kroff, J., Venter, R.E., 2005. The Effect of Backward Locomotion Training on the Body Composition and Cardiorespiratory Fitness of Young Women. Int. J. Sports Med. 26, 214–219. https://doi.org/10.1055/s-2004-820997
  199. Terblanche, E., Wessels, J.A., Stewart, R.I., Koeslag, J.H., 1999. A computer simulation of free-range exercise in the laboratory. J. Appl. Physiol. 87, 1386–1391. https://doi.org/10.1152/jappl.1999.87.4.1386
  200. Terblanche, Elmarie, Fourie, P.R., Wessels, J.A., 1999. Assessment of a peak flow whistle in nonasthmatic children. Pediatr. Pulmonol. 27, 428–431. https://doi.org/10.1002/(SICI)1099-0496(199906)27:6<428::AID-PPUL11>3.0.CO;2-O
  201. Toit, E.F., Nabben, M., Lochner, A., 2005. A potential role for angiotensin II in obesity induced cardiac hypertrophy and ischaemic/reperfusion injury. Basic Res. Cardiol. 100, 346–354. https://doi.org/10.1007/s00395-005-0528-5
  202. Tromp, S., Lochner, E., Lochner, R.C., 1998. Effects of halothane on post-cardiplegic functional recovery - the role of cardioplegic solution. Cardiovasc. J. Afr. 9, 96–98.
  203. Upton, J.J., Huisamen, B., Lochner, A., 2002. Manipulation of papillary muscle cyclic nucleotides during anoxia-reoxygenation: Effects on contractility. Cardiovasc. J. South Africa 13, 10–16.
  204. Uys, J.D.K., Hattingh, S.M., Stein, D.J., Daniels, W.M.U., 2008. Large Scale Hippocampal Cellular Distress may Explain the Behavioral Consequences of Repetitive Traumatic Experiences-A Proteomic Approach. Neurochem. Res. 33, 1724–1734. https://doi.org/10.1007/s11064-008-9615-y
  205. UYS, J.D.K., MARAIS, L., FAURE, J., PREVOO, D., SWART, P., MOHAMMED, A.H., STEIN, D.J., DANIELS, W.M.U., 2006. Developmental Trauma is Associated with Behavioral Hyperarousal, Altered HPA Axis Activity, and Decreased Hippocampal Neurotrophin Expression in the Adult Rat. Ann. N. Y. Acad. Sci. 1071, 542–546. https://doi.org/10.1196/annals.1364.060
  206. Uys, J.D.K., Muller, C.J.F., Marais, L., Harvey, B.H., Stein, D.J., Daniels, W.M.U., 2006. Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: Reversal by escitalopram. Neuroscience 137, 619–625. https://doi.org/10.1016/J.NEUROSCIENCE.2005.08.089
  207. Uys, J.D.K., Stein, D.J., Daniels, W.M.U., Harvey, B.H., 2003. Animal models of anxiety disorders. Curr. Psychiatry Rep. 5, 274–281. https://doi.org/10.1007/s11920-003-0056-7
  208. Uys, Joachim D. K., Stein, D.J., Daniels, W.M.U., 2006. Neuroproteomics: Relevance to anxiety disorders. Curr. Psychiatry Rep. 8, 286–290. https://doi.org/10.1007/s11920-006-0064-5
  209. van Jaarsveld, F.P., Hattingh, S., 2012. Rapid induction of ageing character in brandy products. Ageing and general overview. South African J. Enol. Vitic. 33, 225–252. https://doi.org/10.21548/33-2-1122
  210. van Jaarsveld, F.P., Hattingh, S., Minnaar, P., 2009. Rapid induction of ageing character in brandy products - Part III. Influence of toasting. South African J. Enol. Vitic. 30, 24–37. https://doi.org/10.21548/30-1-1421
  211. van Rensburg, S.J., van Zyl, J., Hon, D., Daniels, W., Hendricks, J., Potocnik, F., Erasmus, R., 2004. Biochemical Model for Inflammation of the Brain: The Effect of Iron and Transferrin on Monocytes and Lipid Peroxidation. Metab. Brain Dis. 19, 97–112. https://doi.org/10.1023/B:MEBR.0000027421.33085.8b
  212. van Rensburg, S.J., van Zyl, J.M., Potocnik, F.C. V., Daniels, W.M.U., Uys, J., Marais, L., Hon, D., van der Walt, B.J., Erasmus, R.T., 2006. The effect of stress on the antioxidative potential of serum: implications for Alzheimer's disease. Metab. Brain Dis. 21, 163–171. https://doi.org/10.1007/s11011-006-9020-7
  213. Van Rooyen, J., Du Toit, E.F., Lochner, A., Rossouw, E., 2005. Proposed mechanisms for the anabolic steroid-induced increase in myocardial susceptibility to ischaemia / reperfusion injury?: cardiovascular topic. Cardiovasc. J. South Africa 16, 21–28.
  214. Van Rooyen, J., Esterhuyse, A.J., Engelbrecht, A.M., Du Toit, E.F., 2008. Health benefits of a natural carotenoid rich oil: A proposed mechanism of protection against ischaemia/reperfusion injury. Asia Pac. J. Clin. Nutr. 17, 316–319.
  215. van Vuuren, D., Genis, A., Genade, S., Lochner, A., 2008a. Postconditioning the Isolated Working Rat Heart. Cardiovasc. Drugs Ther. 22, 391–397. https://doi.org/10.1007/s10557-008-6119-6
  216. van Vuuren, D., Lochner, A., 2008b. Ischaemic postconditioning: from bench to bedside ... Cardiovasc. J. Afr. 19, 311–20.
  217. Varghese, A.C., du Plessis, S.S., Agarwal, A., 2008a. Male gamete survival at stake: causes and solutions. Reprod. Biomed. Online 17, 866–880. https://doi.org/10.1016/S1472-6483(10)60416-6
  218. Varghese, A.C., du Plessis, S.S., Falcone, T., Agarwal, A., 2008b. Cryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes: Challenges for fertility preservation. Reprod. Biol. Endocrinol. 6, 47. https://doi.org/10.1186/1477-7827-6-47
  219. Veliotes, D.G.A., Norton, G.R., Correia, R.J., Strijdom, H., Badenhorst, D., Brooksbank, R., Woodiwiss, A.J., 2010. Impact of Aldosterone Receptor Blockade on the Deleterious Cardiac Effects of Adrenergic Activation in Hypertensive Rats. J. Cardiovasc. Pharmacol. 56, 203–211. https://doi.org/10.1097/FJC.0b013e3181e92a01
  220. Vos, R., Goslett, N., Van Hoogstraten, A., Fourie, P., 1993. Albatros: an innovative low-cost wheelchair. Disabil. Rehabil. 15, 44–46. https://doi.org/10.3109/09638289309165870
  221. Vosberg, H.-P., Moolman, J., D?hlemann, C., McKeown, P., Reith, S., 2000. Analysis of inherited causes of hypertrophic cardiomyopathy as part of clinical practice, in: From Molecule to Men. Steinkopff, Heidelberg, pp. 69–75. https://doi.org/10.1007/978-3-642-57724-6_5
  222. Webster, I., Friedrich, S.O., Lochner, A., Huisamen, B., 2010. AMP kinase activation and glut4 translocation in isolated cardiomyocytes. Cardiovasc. J. Afr. 21, 72–8.
  223. Wiid, I.J., Huisamen, B., 1993. An inexpensive approach to ultracentrifugation of small volume suspensions. Biotechniques 14, 564.
  224. Yapo, G.A., Stefan, S. du P., Nicole, B., 2009. Impact of organic hydroperoxides on rat testicular tissue and epididymal sperm. African J. Biotechnol. 8, 6416–6424. https://doi.org/10.5897/AJB09.773
  225. Yarom, R., Harper, I.S., Wynchank, S., van Schalkwyk, D., Madhoo, J., Williams, K., Salie, R., Genade, S., Lochner, A., 1993. Effect of Captopril on Changes in Rats' Hearts Induced by Long-Term Irradiation. Radiat. Res. 133, 187. https://doi.org/10.2307/3578356?