Recent Publications
???Journal Articles (subsidised)
ALBERTYN CC, VAN NIEKERK A, DUFFY S, AVERY VM, STRAUSS E, CHELLAN P. Investigation of bioorganometallic artemisinins as antiplasmodials. Journal of Organometallic Chemistry 2023; 987-988:122633: 14.
AVENANT C, BICK AJ, SKOSANA SB, DLAMINI S, BALAKRISHNA Y, MOLIKI JM, SINGATA-MADLIKI M, HOFMEYR GJ, STORBECK K, AFRICANDER DJ, ET AL. Misreporting contraceptive use and the association of peak study progestin levels with weight and BMI among women randomized to the progestin-only injectable contraceptives DMPA-IM and NET-EN. PLoS One 2023; 18(12):e0295959, 21 pages.
BARRY CJ, PILLAY CS, ROHWER JM. Modelling the Decamerisation Cycle of PRDX1 and the Inhibition-like Effect on Its Peroxidase Activity. Antioxidants 2023; 12:1707, 21 pages.
BRIGG SE, KOEKEMOER L, BRAND LA, STRAUSS E. Multifaceted Target Specificity Analysis as a Tool in Antimicrobial Drug Development: Type III Pantothenate Kinases as a Case Study. ChemMedChem 2023; 18:e202200630, 10 pages.
CARTWRIGHT M, LOUW-DU TOIT R, AFRICANDER DJ. The transcriptional activity of progestins used in contraception and menopausal hormone therapy via progesterone receptor A is dependent on the density of the receptor. Biochemical and Biophysical Research Communications 2023; 639:70-76.
CARTWRIGHT M, LOUW-DU TOIT R, JACKSON HC, SHARP M, AFRICANDER DJ. Progesterone receptor isoform ratios influence the transcriptional activity of progestins via the progesterone receptor. Journal of Steroid Biochemistry and Molecular Biology 2023; 232:106348, 13 pages.
CLEMENTS-DECKER T, RAUTENBACH M, VAN RENSBURG W, KHAN S, STANDER MA, KHAN W. Secondary metabolic profiling of Serratia marcescens NP10 reveals new stephensiolides and glucosamine derivatives with bacterial membrane activity. Scientific Reports 2023; 13(1):2360, 14 pages.
GENT R, BARBIER ID, ATKIN SL, NEWELL-FUGATE AE, SWART AC. Ultra-performance convergence chromatography tandem mass spectrometry analysis of adrenal and gonodal steroid hormones in southern white rhinoceros (Ceratotherium simum simum) faeces and serum. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2023; 1215:123576: 14 pages.
JACKSON HC, PHEIFFER C, JACK BU, AFRICANDER DJ. Time- and glucose-dependent differentiation of 3T3-L1 adipocytes mimics dysfunctional adiposity. Biochemical and Biophysical Research Communications 2023; 671:286-291.
KOURIL T, OCTOBER CA, HOLLOCKS SA, ODENDAAL JCW, VAN NIEKERK DD, SNOEP JL. Inhibitor titrations reveal low control of glyceraldehyde 3-phosphate dehydrogenase and high control of hexokinase on glycolytic flux in an aggressive triple-negative breast cancer cell line. Biosystems 2023; 231:104969, 8 pages.
KRAUSE T, WIESINGER P, GONZ?LEZ-CABANELAS D, LACKUS N, K?LLNER TG, KL?PFEL T, WILLIAMS J, ROHWER JM, GERSHENZON J, SCHMIDT A. HDR, the last enzyme in the MEP pathway, differently regulates isoprenoid biosynthesis in two woody plants. Plant Physiology 2023; 192:767-788.
KUMAR V, VAN RENSBURG W, SNOEP JL, PARADIES HH, BORRAGEIRO CM, DE VILLIERS C, SINGH R, JOSHI KB, RAUTENBACH M. Antimicrobial nano-assemblies of tryptocidine C, a tryptophan-rich cyclic decapeptide, from ethanolic solutions. Biochimie 2023; 204:22-32.
LATEGAN FA, SCHREIBER C, PATTERTON H. SeqPredNN: a neural network that generates protein sequences that fold into specified tertiary structures. BMC Bioinformatics 2023; 24:373, 14 pages.
LAUTERBACH S, DIENHART H, RANGE J, MALZACHER S, SP?RING JD, ROTHER D, FILIPA PINTO M, MARTINS P, ROHWER JM, ET AL. EnzymeML: seamless data flow and modeling of enzymatic data. Nature Methods 2023; 20:400-402.
MABIZELA GS, VAN DER RIJST M, SLABBERT MM, MATHABE PMK, MULLER M, DE BEER D, STANDER MA, COLLING J, WALCZAK B, JOUBERT E, BESTER C. Response of Cyclopia subternata to drought stress - assessment of leaf composition, proteomics and product quality. South African Journal of Botany 2023; 161:96-112.
MAFATA MO, WILLIAMS C, KRUGER MG, BRAND J, WATSON BW, BUICA AS. Unsupervised data fusion and interpretation through cluster analysis on biplot projections: craft beer and gin case studies. EUROPEAN FOOD RESEARCH AND TECHNOLOGY 2023; 249(4):1073-1087.
MILLET V, GENSOLLEN T, MALTESE M, SERRERO M, LESAVRE N, BOURGES C, PITAVAL C, MOSTERT KJ, STRAUSS E, ET AL. Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis. GUT 2023; 72:1115-1128.
NEIBURGA KD, MUIZNIEKS R, ZAKE DM, PENTJUSS A, KOMASILOVS V, ROHWER JM, TISSIER A, STALIDZANS E. Total optimization potential (TOP) approach based constrained design of isoprene and cis-abienol production in A. thaliana. Biochemical Engineering Journal 2023; 190:108723, 11 pages.
OLAYOKU FR, VERHOOG NJD, LOUW A. Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist. Frontiers in Pharmacology 2023; 14:1122031, 19 pages.
PFUKWA NBC, RAUTENBACH M, HUNT NT, OLAOYE OO, KUMAR V, PARKER AW, MINNES L, NEETHLING PH. Temperature-Induced Effects on the Structure of Gramicidin S. Journal of Physical Chemistry B 2023; 127:3774-3786.
PILLAY CS, JOHN N, BARRY CJ, MTHETHWA LMDC, ROHWER JM. Atypical network topologies enhance the reductive capacity of pathogen thiol antioxidant defense networks. Redox Biology 2023; 65:102802, 7 pages.
RAMATSUI L, DONGOLA TH, ZININGA T, MULTHOFF G, SHONHAI A. Human granzyme B binds Plasmodium falciparum Hsp70?x and mediates antiplasmodial activity in vitro. Cell Stress and Chaperones 2023; 28:321-331.
SAHA ST, ABDULLA N, ZININGA T, SHONHAI A, WADEE R, KAUR M. 2-Hydroxypropyl-?-cyclodextrin (HP?CD) as a Potential Therapeutic Agent for Breast Cancer. Cancers 2023; 15:2828, 23 pages.
SHEIK ABDUL N, MARNEWICK JL. Fumonisin B1 disrupts mitochondrial function in oxidatively poised HepG2 liver cells by disrupting oxidative phosphorylation complexes and potential participation of lincRNA-p21. Toxicon 2023; 225:107057, 8 pages.
STORBECK K, OREILLY MW. The clinical and biochemical significance of 11-oxygenated androgens in human health and disease. European Journal of Endocrinology 2023; 188:R98-R109.
VAN NIEKERK DD, DU TOIT F, GREEN KA, PALM DC, SNOEP JL. A detailed kinetic model of glycolysis in Plasmodium falciparum-infected red blood cells for antimalarial drug target identification. JOURNAL OF BIOLOGICAL CHEMISTRY 2023; 299(9):105111, 14 pages.
VAN NIEKERK DD, RUST FC, BRUGGEMAN F, WESTERHOFF H, SNOEP JL. Is distance from equilibrium a good indicator for a reaction's flux control?. Biosystems 2023; 232:104988, 8 pages.
WILLIAMS C, STANDER MA, MEDVEDOVICI A, BUICA AS. Volatile terpenoid profiling in gin and beer – A targeted approach. Journal of Food Composition and Analysis 2023; 118:105178; 10 pages.
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Journal Articles (non-subsidised)
TIMOTHY FM, ZININGA T. Small heat shock proteins as modulators of cell death in Plasmodium falciparum parasites and its human host. Frontiers in Cell Death 2023; 2:1322780, 20 pages.
Chapters in Books
SWART AC, VAN ROOYEN D, DU TOIT T. Investigating the biosynthesis and metabolism of 11β-hydroxyandrostenedione. In: Penning TM (ed.) METHODS IN ENZYMOLOGY Steroid Biochemistry, Academic press, Elsevier Inc. Cambridge, USA, 2023: 389-433.
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Doctorals completed
Click here for an up-to-date list.
JENKINS B. Discovery of novel anti-Candida albicans compounds from environmental bacteria. PhD, 2023. 166 pp. Promotor: RAUTENBACH M. Medepromotor: SNOEP JL.
MOCKE L. Kinetic characterisation and mathematical modelling of the coenzyme A biosynthesis salvage pathway in Mycobacterium tuberculosis. PhD, 2023. 101 pp. Promotor: SNOEP JL. Medepromotor: STRAUSS E.
VAN DER MERWE PDW. Phylogenetic analyses in the African fish genus Nothobranchius in relation to landscape evolution. PhD, 2023. 453 pp. Promotor: BELLSTEDT DU. Medepromotor: COTTERILL FPD, Schliewen UK.
WILLIAMS C. To target or not to target: strategies for the aroma analysis of alcoholic beverages. PhD, 2023. 260 pp. Promotor: BUICA AS. Medepromotor: STANDER MA, Medvedovici A.
Masters completed
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BORRAGEIRO CM. Formulation of natural cyclodecapeptides for surface sterilisation. MSc, 2023. 174 pp. Studieleier: RAUTENBACH M.
BOTHA DD. Investigation into the assimilation of free amino nitrogen from bread waste during yeast proliferation. MSc, 2023. 120 pp. Studieleier: HAYWARD S. Medestudieleier: TAIT T, STRAUSS E.
BUCK AC. Examining the effect of C-reactive protein on the regulation of the FOXO1 transcription factor in a liver cell line. MSc, 2023. 149 pp. Studieleier: VERHOOG NJD. Medestudieleier: AFRICANDER DJ.
CAILLET C. Characterisation of the cytosolic Plasmodium falciparum Hsp90 and Hsp70-z chaperone proteins. MSc, 2023. 73 pp. Studieleier: ZININGA T. Medestudieleier: DE VILLIERS M.
DE VILLIERS C. Metal and tyrocidine nano-assemblies to create broad-spectrum metal-peptide formulations. MSc, 2023. 157 pp. Studieleier: RAUTENBACH M.
HOLLOCKS SA. Metabolic control analysis using glycolytic inhibitor titrations in the MCF-7 breast cancer cell line. MSc, 2023. 91 pp. Studieleier: SNOEP JL. Medestudieleier: KOURIL T, VAN NIEKERK DD.
KITSHOFF R. Determining the extent of antibiotic resistance in ostrich chick production systems. MSc, 2023. 154 pp. Studieleier: BOTES A.
LEUKES KA. Studies of mitophagy in mouse and fish models using antibodies and PCR. MSc, 2023. 100 pp. Studieleier: BELLSTEDT DU. Medestudieleier: LOOS B.
MARKGRAAFF MJ. An investigation into the effect of metabolism on 11-ketotesosterone activity using in vitro models. MSc, 2023. 82 pp. Studieleier: STORBECK K.
NEL TI. Genomic comparison of two ostrich-infecting Mycoplasma species. MSc, 2023. 117 pp. Studieleier: BOTES A. Medestudieleier: PATTERTON H.
PETERSEN AV. Investigating the effects of glucocorticoids and pro-inflammatory cytokines on oxidative stress in the HepG2 cell line. MSc, 2023. 112 pp. Studieleier: VERHOOG NJD. Medestudieleier: LOUW-DU TOIT R.
REID JL. Resisting the molecular evolution of fitness: An investigation into the role of ploidy in the perturbed adaptability observed in an HTZ1 knockout. MSc, 2023. 132 pp. Studieleier: PATTERTON H.
STOFBERG ML. Characterisation of the Plasmodium falciparum ER-localised Hsp90-Hsp110 chaperone complex. MSc, 2023. 90 pp. Studieleier: ZININGA T. Medestudieleier: STRAUSS E.
VAN SCHALKWYK CE. Understanding yeast glycolysis dynamics using HPLC analysis and mathematical modelling. MSc, 2023. 72 pp. Studieleier: VAN NIEKERK DD. Medestudieleier: SNOEP JL.?
